Minocycline induced drug rash with eosinophilia and systemic symptoms complicated by hemophagocytic lymphohistiocytosis

Raymond Zhao^{1

2}, Elisabeth A Pedersen², Jennifer Brescoll Mancuso²

Affiliations

¹ University of Michigan Medical School, Ann Arbor, Michigan.
² Department of Dermatology, University of Michigan Medicine, Ann Arbor, Michigan.

PMID: 36698373
PMCID: PMC9867947
DOI: 10.1016/j.jdcr.2022.11.006

Case Reports

Minocycline induced drug rash with eosinophilia and systemic symptoms complicated by hemophagocytic lymphohistiocytosis

Raymond Zhao et al. JAAD Case Rep. 2022.

. 2022 Nov 11:32:99-101.

doi: 10.1016/j.jdcr.2022.11.006. eCollection 2023 Feb.

Authors

Raymond Zhao^{1

2}, Elisabeth A Pedersen², Jennifer Brescoll Mancuso²

Affiliations

¹ University of Michigan Medical School, Ann Arbor, Michigan.
² Department of Dermatology, University of Michigan Medicine, Ann Arbor, Michigan.

PMID: 36698373
PMCID: PMC9867947
DOI: 10.1016/j.jdcr.2022.11.006

No abstract available

Keywords: DRESS syndrome; DRESS, drug rash with eosinophilia and systemic symptoms; HLH, hemophagocytic lymphohistiocytosis; IL, interleukin; hemophagocytic lympohistiocystosis; minocycline.

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Conflict of interest statement

None disclosed.

Cited by

Case Report: Minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review.
Zhao Z, Lu M, Ying Y. Zhao Z, et al. Front Pharmacol. 2024 Mar 7;15:1355774. doi: 10.3389/fphar.2024.1355774. eCollection 2024. Front Pharmacol. 2024. PMID: 38515844 Free PMC article.
Trimethoprim/sulfamethoxazole and risk of haemophagocytic lymphohistiocytosis (HLH): a literature review and disproportionality analysis using individual case safety reports from FAERS.
Lau R, Sadeghi H, Ahmadi F, Chalabianloo N, Preyra R, Omrani MA, Muanda FT. Lau R, et al. J Antimicrob Chemother. 2025 Sep 3;80(9):2421-2427. doi: 10.1093/jac/dkaf231. J Antimicrob Chemother. 2025. PMID: 40660905 Free PMC article. Review.

References

1. Husain Z., Reddy B.Y., Schwartz R.A. DRESS syndrome: part I. Clinical perspectives. J Am Acad Dermatol. 2013;68(5):693.e1-14. quiz 706-8. - PubMed
1. Canna S.W., Marsh R.A. Pediatric hemophagocytic lymphohistiocytosis. Blood. 2020;135(16):1332–1343. - PMC - PubMed
1. Garrido-Mesa N., Zarzuelo A., Gálvez J. Minocycline: far beyond an antibiotic. Br J Pharmacol. 2013;169(2):337–352. - PMC - PubMed
1. Sharifzadeh S., Mohammadpour A.H., Tavanaee A., Elyasi S. Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review. Eur J Clin Pharmacol. 2021;77(3):275–289. - PMC - PubMed
1. Prejean R., Haas C. Recalcitrant minocycline-induced DRESS mimicking HLH. Dermatol Ther. 2020;33(6) - PubMed

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Minocycline induced drug rash with eosinophilia and systemic symptoms complicated by hemophagocytic lymphohistiocytosis

Affiliations

Minocycline induced drug rash with eosinophilia and systemic symptoms complicated by hemophagocytic lymphohistiocytosis

Authors

Affiliations

Conflict of interest statement

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References

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