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Review
. 2023 Jan 9:9:1052504.
doi: 10.3389/fnut.2022.1052504. eCollection 2022.

Bioactive components, pharmacological effects, and drug development of traditional herbal medicine Rubus chingii Hu (Fu-Pen-Zi)

Beihui He  1 , Linghao Dai  1 , Li Jin  1 , Yuan Liu  1 , Xiaojuan Li  1 , Minmin Luo  1 , Zhian Wang  2 , Guoyin Kai  1   3
Affiliations
Review

Bioactive components, pharmacological effects, and drug development of traditional herbal medicine Rubus chingii Hu (Fu-Pen-Zi)

Beihui He et al. Front Nutr. .

Abstract

Rubus chingii Hu (Chinese Raspberry), known as Fu-Pen-Zi in Chinese, a woody perennial plant of the genus Rubus in the Rosaceae family, has specific nutritional and medicinal values, which is considered food-medicine herb in China for thousands of years to treat impotence, premature ejaculation, enuresis, frequent urination, and other diseases. This review aims to summarize recent advances in the bioactive components, pharmacological effects, and drug development and utilization of Rubus chingii Hu, hoping to provide useful support for its further research and clinical application. The bioactive components in Rubus chingii Hu contain mainly terpenoids, flavonoids, alkaloids, phenolic acids, polysaccharides, and steroids. The main pharmacological effects are their anti-oxidant, anti-inflammatory, and anti-tumor capacity on human health. Rubus chingii Hu is a very valuable food-medicine herb. The development of Rubus chingii Hu-related drugs is relatively single, which is limited to traditional Chinese medicine and prescriptions. Therefore, it is vital to pay interest to Rubus chingii Hu and its bioactive components in the future and extend its scientific application.

Keywords: Rubus chingii Hu; bioactive components; drug development; pharmacological effects; quality control.

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Conflict of interest statement

ZW was employed by Zhejiang Research Institute of Traditional Chinese Medicine Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Plant, flowers, dried fruitlet of R. chingii Hu (Fu-Pen-Zi) and related Chinese medicines. (A) Plant of R. chingii Hu, (B) Flowers, (C) WuziYanzong Pill, and (D) Dried fruitlet (Fu-Pen-Zi).
Figure 2
Figure 2
The portion of different components of R. chingii Hu.
Figure 3
Figure 3
Main compounds chemical structures in R.chingii Hu.
Figure 4
Figure 4
The most important pharmacological effects and potential mechanisms of R. chingii Hu.
Figure 5
Figure 5
Drug development and utilization status of R.chingii Hu.
See this image and copyright information in PMC

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