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. 2023 Jan 9:9:1007725.
doi: 10.3389/fnut.2022.1007725. eCollection 2022.

The association between vitamin D status and inflammatory bowel disease among children and adolescents: A systematic review and meta-analysis

Somaye Fatahi  1   2 , Naseem Alyahyawi  3 , Naryman Albadawi  4 , Farzaneh Mardali  2 , Naghi Dara  1 , Mohammad Hassan Sohouli  5 , Kousalya Prabahar  6 , Pejman Rohani  7 , Nazanin Koushki  2 , Aliakbar Sayyari  1 , Amir Hossein Hosseini  1 , Ahmed Abu-Zaid  8
Affiliations

The association between vitamin D status and inflammatory bowel disease among children and adolescents: A systematic review and meta-analysis

Somaye Fatahi et al. Front Nutr. .

Abstract

Aim: Vitamin D deficiency is very common among children with IBD. Since there are conflicting results regarding the association of vitamin D with IBD, we conducted this systematic review to confirm the association of vitamin D with IBD.

Methods: We conducted a systematic search in Scopus, Cochrane Library, Web of Science, PubMed, and Google Scholar to find relevant studies. Articles with cross-sectional and case-control designs that reported the association between vitamin D and IBD among children were included.

Results: Eventually, 9 studies (with 16 effect sizes) reported the mean and SD or the median and the interquartile range of serum vitamin D levels in both subjects with IBD and control subjects. The random effects meta-analysis revealed that subjects with IBD had -1.159 ng/ml (95% CI: -2.783, 0.464) lower serum vitamin D concentrations compared with their healthy counterparts, but this difference was not significant. A total of 14 studies (with 18 effect sizes) with 2,602 participants provided information for the prevalence of vitamin D deficiency or insufficiency in patients with IBD as 44% (95% CI: 0.34-0.54) with significant heterogeneity noted among studies (p < 0.001; I2 = 97.31%).

Conclusion: This systematic and meta-analysis study revealed that vitamin D deficiency was associated with IBD. Longitudinal studies should be conducted in the future to confirm our findings. Large randomized controlled trials assessing the doses of supplementation of vitamin D would provide a better understanding of the association between vitamin D and IBD.

Keywords: children; inflammatory bowel disease (IBD); supplement; systematic review; vitamin D.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the included studies, including identification, screening, eligibility and the final sample included.
Figure 2
Figure 2
Forest plot show the WMD in serum vitamin D concentrations between participants with IBD and healthy control.
Figure 3
Figure 3
Pooled estimate of the prevalence of vitamin D deficiency or insufficiency in children and adolescence with IBD, UC, and CD.
Figure 4
Figure 4
Pooled estimate of the prevalence of vitamin D status in children and adolescence with IBD.
See this image and copyright information in PMC

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