Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Assessment of genetically modified maize MON 87419 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2017-140)

EFSA Panel on Genetically Modified Organisms (GMO) et al. EFSA J. .

Abstract

Genetically modified maize MON 87419 was developed to confer tolerance to dicamba- and glufosinate-based herbicides. These properties were achieved by introducing the dmo and pat expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize MON 87419 and its conventional counterpart needed further assessment, except for the levels of arginine and protein in grains which did not raise safety and nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the dicamba mono-oxygenase (DMO) and phosphinothricin N-acetyltransferase (PAT) proteins as expressed in maize MON 87419. The GMO Panel finds no evidence that the genetic modification impacts the overall safety of maize MON 87419. In the context of this application, the consumption of food and feed from maize MON 87419 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize MON 87419 is as safe as the conventional counterpart and non-GM maize varieties tested, and no post-market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize MON 87419 grains into the environment, this would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize MON 87419. The GMO Panel concludes that maize MON 87419 is as safe as its conventional counterpart and the tested non-GM maize varieties with respect to potential effects on human and animal health and the environment.

Keywords: DMO; GM; MON 87419; PAT; genetic engineering; import and processing; maize (Zea mays).

PubMed Disclaimer

Similar articles

Cited by

References

    1. Berg G, Roskot N and Smalla K, 1999. Genotypic and phenotypic relationships between clinical and environmental isolates of Stenotrophomonas maltophilia. Journal of Clinical Microbiology, 37, 3594–3600. - PMC - PubMed
    1. Breiteneder H and Mills EN, 2005. Molecular properties of food allergens. Journal of Allergy and Clinical Immunology, 115, 14–23. - PubMed
    1. Calza L, Manfredi R and Chiodo F, 2003. Stenotrophomonas (Xanthomonas) maltophilia as an emerging opportunistic pathogen in association with HIV infection: A 10‐year surveillance study. Infection, 31, 155–161. 10.1007/s15010-003-3113-6 - DOI - PubMed
    1. Codex Alimentarius , 2009. Foods derived from modern biotechnology. Codex Alimentarius Commission, Joint FAO/WHO Food Standards Programme, Rome, Italy. 85 pp. Available online. https://www.fao.org/docrep/011/a1554e/a1554e00.htm
    1. Costa J, Bavaro SL, Benede S, Diaz‐Perales A, Bueno‐Diaz C, Gelencser E, Klueber J, Larre C, Lozano‐Ojalvo D, Lupi R, Mafra I, Mazzucchelli G, Molina E, Monaci L, Martın‐Pedraza L, Piras C, Rodrigues PM, Roncada P, Schrama D, Cirkovic‐Velickovic T, Verhoeckx K, Villa C, Kuehn A, Hoffmann‐Sommergruber K and Holzhauser T, 2022. Are physicochemical properties shaping the allergenic potency of plant allergens? Clinical Reviews in Allergy and Immunology, 62, 37–63. 10.1007/s12016-020-08810-9 - DOI - PubMed