Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan 19;6(1):e1053.
doi: 10.1002/hsr2.1053. eCollection 2023 Jan.

Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross-sectional study

Emmanuel K Ofori  1 , Christian N Adekena  1   2 , Vincent Boima  3 , Henry Asare-Anane  1 , Ernest Yorke  3 , Eric N Y Nyarko  1 , Bismark N Mohammed  1 , Emmanuel Quansah  2 , Sisitha U Jayasinghe  4 , Seth D Amanquah  1
Affiliations

Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross-sectional study

Emmanuel K Ofori et al. Health Sci Rep. .

Abstract

Background and aim: Adipocytes secrete a peptide hormone called leptin, which plays a crucial role in controlling appetite and energy expenditure. Alterations in leptin concentrations are associated with CKD-related cardiovascular problems such as hypertensive heart disease (HHD). Despite the link, data on the precise function of leptin in people with CKD and HHD is scant.

Methods: An observational cross-sectional study involving a total of 108 participants (72 CKD patients with HHD and 36 healthy controls). Their demographic and anthropometric information was collected using a standardized questionnaire. Certain clinical measures such as blood pressure and body mass index (BMI) were assessed. Fasting blood samples were analyzed for levels of plasma glucose (FPG), lipids, creatinine, and leptin. Data were analyzed with SPSS v23.

Results: Leptin, FPG, creatinine and triglyceride levels were all significantly higher in CKD patients with HHD compared to controls (p < 0.01 for all). Furthermore, advanced CKD status (being in stage 5), having a 6-year diagnosis of HHD, being female, having a higher BMI, and elevation in levels of HDL and FPG contributed significantly to the variance in serum leptin levels in the case group (β = 0.37, 0.22, 0.19, 0.18, 0.27, 0.28; p < 0.05 for all). In the control group, the female gender had the biggest unique effect on circulating leptin levels, followed by BMI and eGFR (β = 0.71, 0.34, -0.22; p < 0.01 for all).

Conclusion: Patients with CKD who also had HHD reported considerably higher circulating leptin levels. Significantly higher blood leptin levels were shown to be associated with CKD stage 5 in the case group. These results are consistent with the role of leptin in the metabolic complexity seen in CKD patients. There needs to be more research into treatments that aim to lower leptin levels in CKD patients with HHD.

Keywords: body mass index; chronic kidney disease; glomerular filtration rate; hypertension; leptin.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

References

    1. Ammirati AL. Chronic kidney disease. Rev Assoc Med Bras. 2020;66:s03‐s09. - PubMed
    1. Noble R, Taal MW. Epidemiology and causes of chronic kidney disease. Medicine. 2019;47(9):562‐566.
    1. Kalantar‐Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V. Chronic kidney disease. The lancet. 2021;398(10302):786‐802. - PubMed
    1. Webster AC, Nagler EV, Morton RL, Masson P. Chronic kidney disease. Lancet. 2017;389(10075):1238‐1252. - PubMed
    1. Naicker S, Ashuntantang G. End stage renal disease in sub‐Saharan Africa. Chronic Kidney Disease in Disadvantaged Populations. Elsevier; 2017:125‐137.