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. 2023 Jan 9:13:1043595.
doi: 10.3389/fendo.2022.1043595. eCollection 2022.

Pharmacologic management of weight regain following bariatric surgery

Eugene Lucas  1 , Okeefe Simmons  1 , Beverly Tchang  1 , Louis Aronne  1
Affiliations

Pharmacologic management of weight regain following bariatric surgery

Eugene Lucas et al. Front Endocrinol (Lausanne). .

Abstract

While bariatric surgery restults in significant long-term weight loss for most patients with obesity, post-surgical weight gain affects a considerable percentage of patients to varying degrees of severity. Furthermore, a small but significant percentage of patients experience inadequate post-surgical weight loss. Although many studies have examined the role of anti-obesity medications to address post-operative weight regain, an evidence-based consensus has not yet been achieved because of the heterogeneity of populations studied and the studies themselves. Observational studies in the post-bariatric surgery population consistently demonstrate the benefit of medical weight management after bariatric surgery, with most evidence highlighting liraglutide, topiramate, and phentermine/topiramate. New anti-obesity medications are anticipated to be helpful for post-surgical weight optimization given their efficacy in the non-surgical population.

Keywords: anti-obesity medications; bariatric (weight loss) surgery; obesity; obesity pharmacotherapy; weight regain after bariatric surgery.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

    1. American Society for Metabolic and Bariatric Surgery . Estimate of bariatric surgery numbers, 2011-2020. Available at: https://asmbs.org/resources/estimate-of-bariatric-surgery-numbers.
    1. King WC, Hinerman AS, Belle SH, Wahed AS, Courcoulas AP. Comparison of the performance of common measures of weight regain after bariatric surgery for association with clinical outcomes. JAMA (2018) 320(15):1560–9. doi: 10.1001/jama.2018.14433 - DOI - PMC - PubMed
    1. Sjöström L. Review of the key results from the Swedish obese subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. J Intern Med (2013) 273(3):219–34. doi: 10.1111/joim.12012 - DOI - PubMed
    1. Sjöström L, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Carlsson B, et al. . Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med (2004) 351(26):2683–93. doi: 10.1056/NEJMoa035622 - DOI - PubMed
    1. Baig SJ, Priya P, Mahawar KK, Shah S. Indian Bariatric surgery outcome reporting (IBSOR) group. weight regain after bariatric surgery-a multicentre study of 9617 patients from Indian bariatric surgery outcome reporting group. Obes Surg (2019) 29(5):1583–92. doi: 10.1007/s11695-019-03734-6 - DOI - PubMed