Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul-Sep;18(3):316-323.
doi: 10.4183/aeb.2022.316.

DIAGNOSTIC PERFORMANCES OF 18F-FLUOROCHOLINE POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY AND REPEATED ULTRASONOGRAPHY IN DETECTING UNDEFINED LESIONS IN PATIENTS WITH AN INDICATION FOR PRIMARY HYPERPARATHYROIDISM SURGERY

R Yildiz  1 , H Şan  2 , E Alagöz  3
Affiliations

DIAGNOSTIC PERFORMANCES OF 18F-FLUOROCHOLINE POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY AND REPEATED ULTRASONOGRAPHY IN DETECTING UNDEFINED LESIONS IN PATIENTS WITH AN INDICATION FOR PRIMARY HYPERPARATHYROIDISM SURGERY

R Yildiz et al. Acta Endocrinol (Buchar). 2022 Jul-Sep.

Abstract

Context: 18F-fluorocholine (FCH) has been used as a positron emission tomography (PET) tracer in the localization of hyper-functioning parathyroid glands (HPGs).

Objective: We performed this methodological study to evaluate the diagnostic performance of 18F-FCH PET/computerized tomography (CT) and repeated ultrasonography (USG) in detecting unidentified lesions in patients with primary hyperparathyroidism (PHPT).

Design: In this retrospective methodological study, we studied the diagnostic performance of 18F-FCH PET/CT and a repeated USG in detecting unidentified parathyroid lesions.

Subjects and methods: Twenty-eight patients who were diagnosed with PHPT, had an indication for surgery following the current guidelines and had no identified lesion on 99mTc-MIBI SPECT/CT, USG, or other imaging methods than 18F-FCH PET/CT, included in the study.

Results: While lesions were detected in 26 patients via 18F-FCH PET/CT among 28 patients [92.9% (95% CI: 76.6%-99.1%)], the lesion detection rate was 95.7% (95% CI: 78.1%-99.9%) in 23 patients who underwent a repeated USG. The sensitivity and the accuracy of both 18F-FCH PET/CT and repeated USG were 95.2% (95% CI: 76.2%-99.9%) and 95.0 (95% CI: 75.1%-99.9%), respectively.

Conclusions: This study supports that the combination of 18F-FCH PET/CT and repeated USG has promising potential for being an imaging technique for early detection and localization of HPGs.

Keywords: 18F-Fluorocholine Positron Emission Tomography/Computerized Tomography; Hyperfunctioning Parathyroid Gland; Primary Hyperparathyroidism; Radioguided Occult Lesion Localization-Minimally Invasive Parathyroidectomy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Gass JM, Wicke C, Mona C, Strobel K, Muller W, Metzger J, Suter-Widmer I, Henzen C, Fischli S. 18F-Fluorocholine-PET combined with contrast-enhanced CT for localizing hyperfunctioning parathyroid glands and optimizing surgical treatment in patients with hyperparathyroidism. Endocrine. 2022;75:593–600. - PubMed
    1. Yeh MW, Ituarte PHG, Zhou HC, Nishimoto S, Amy Liu I-L, Harari A, Haigh PI, Adams AL. Incidence and Prevalence of Primary Hyperparathyroidism in a Racially Mixed Population. J Clin Endocrinol Metab. 2013;98:1122–1129. - PMC - PubMed
    1. Walker MD, Silverberg SJ. Primary hyperparathyroidism. Nat Rev Endocrinol. 2018;14:115–125. - PMC - PubMed
    1. Eligal S, Mekel M, Weinberger JM, Neymark M, Hirshoren N, Mizrahi I, Eliashar R, Mazeh H. Minimally Invasive Parathyroidectomy: Can Intraoperative Parathyroid Hormone Monitoring be Omitted? World J Surg. 2022;46(8):1908–1914. - PubMed
    1. Moalem J, Guerrero M, Kebebew E. Bilateral Neck Exploration in Primary Hyperparathyroidism—When Is It Selected and How Is It Performed? World J Surg. 2009;33:2282–2291. - PubMed

LinkOut - more resources