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. 2023 Jan 20;22(1):e12499.
doi: 10.1002/rmb2.12499. eCollection 2023 Jan-Dec.

The gonadotropins starting dose calculator, which can be adjusted the target number of oocytes and stimulation duration days to achieve individualized controlled ovarian stimulation in Japanese patients

Masato Kobanawa  1
Affiliations

The gonadotropins starting dose calculator, which can be adjusted the target number of oocytes and stimulation duration days to achieve individualized controlled ovarian stimulation in Japanese patients

Masato Kobanawa. Reprod Med Biol. .

Abstract

Purpose: To create a gonadotropin starting dose calculator for controlled ovarian stimulation, which can adjust the target number of oocytes and stimulation duration for each facility to achieve individualized controlled ovarian stimulation among the Japanese patients.

Methods: The patients received controlled ovarian stimulation using the gonadotropin-releasing hormone antagonist protocol, and oocytes were retrieved. Using single regression analysis, we selected age, anti-Müllerian hormone (AMH), and initial serum follicle-stimulating hormone as variables to predict the number of oocytes retrieved per gonadotropin dose (oocyte sensitivity index). Each variable was then analyzed using backward stepwise multiple regression.

Results: Age and AMH were selected as predictive variables from the backward stepwise multiple regression, and we developed a multiple regression equation. We decomposed the equation as the number of oocytes retrieved/(gonadotropin starting dose × stimulation duration days) and created a calculation formula to predict the gonadotropin starting dose from the target number of oocytes and stimulation duration days.

Conclusions: This is the first study to develop an individualized dosing algorithm for gonadotropins among Japanese patients. Our calculator will improve controlled ovarian stimulation performance and enable national standardization by allowing all physicians, regardless of their years of experience, to determine the appropriate starting dose of gonadotropins equally.

Keywords: gonadotropins starting dose; individualized controlled ovarian stimulation; ovarian sensitivity index; stimulation duration; target number of oocytes.

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Conflict of interest statement

The authors declare no conflicts of interest associated with this article. All the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (facilityal and national) and with the Helsinki Declaration of 1964 and its later amendments. Informed consent was obtained from all patients for being included in the study. This article does not contain any studies with animal subjects performed by any of the authors. The protocol for the research project, including human subjects, has been approved by a suitably constituted Ethics Committee, ‘Medical corporation Kobanawa Clinic ethic screening committee’.

Figures

FIGURE 1
FIGURE 1
Display of the gonadotropins starting dose calculator is demonstrated
FIGURE 2
FIGURE 2
Calculation results for a 35‐year‐old patient with AMH of 3.0 ng/ml, with a target number of oocytes of 10 and a stimulation period of 11 days
FIGURE 3
FIGURE 3
Calculation results for a 42‐year‐old patient with an AMH of 0.8 ng/ml, with a target number of oocytes of 8 and 13 days of stimulation
See this image and copyright information in PMC

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