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Editorial
. 2023 Jan 26;141(4):327-328.
doi: 10.1182/blood.2022018229.

Anemia and brain hypoxia

John C Wood  1
Affiliations
Editorial

Anemia and brain hypoxia

John C Wood. Blood. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: J.C.W. is a paid member of the National Heart, Lung, and Blood Institute Sickle Cell Disease Advisory Committee and has grant funding from Philips Healthcare. He also serves as a consultant for Agios, Celgene, Imago Biosciences, Pharmacosmos, Regeron, Silence Therapeutics, Vifor, and World Care Clinical.

Figures

None
Schematic illustrating the HVR as a function of hematocrit for patients with SS hemoglobin (untreated), SS hemoglobin (treated with hydroxyurea or chronic transfusions), and AA hemoglobin. HVR is a metric of the microvascular oxygen-delivery potential and balances the positive effects of increased oxygen delivery vs the negative effects of increased viscosity. The hematocrit that optimizes HVR, as well as the peak HVR obtained, is lower in patients with SS compared with those with AA hemoglobin. In SCD, effective therapies must not only increase hemoglobin but improve red cell rheology.
See this image and copyright information in PMC

Comment on

References

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