. 2023 Jan 26;18(1):e0269096.

doi: 10.1371/journal.pone.0269096. eCollection 2023.

Renal function is associated with one-month and one-year mortality in patients with intracerebral hemorrhage

I-Kuan Wang^{1

2}, Tzung-Hai Yen^{3

4}, Chon-Haw Tsai^{1

5}, Yu Sun^{6

7}, Wei-Lun Chang⁸, Po-Lin Chen^{9

10}, Ta-Chang Lai¹¹, Po-Yen Yeh¹², Cheng-Yu Wei¹³, Cheng-Li Lin¹⁴, Kai-Cheng Hsu⁵, Chi-Yuan Li^{15

16}, Fung-Chang Sung^{14

17

18}, Chung Y Hsu¹⁶; Taiwan Stroke Registry Investigators

Affiliations

¹ Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
² Division of Nephrology, China Medical University Hospital, Taichung, Taiwan.
³ Division of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
⁴ Chang Gung University College of Medicine, Taoyuan, Taiwan.
⁵ Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
⁶ Neurology, En Chu Kong Hospital, New Taipei City, Taiwan.
⁷ Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁸ Department of Neurology, Show Chwan Memorial Hospital, Changhua County, Taiwan.
⁹ Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.
¹⁰ Department of Neurology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
¹¹ Division of Neurology Department of Internal Medicine, Cheng Hsin General Hospital, Taipei, Taiwan.
¹² Department of Neurology, St. Martin De Porres Hospital, Chiayi, Taiwan.
¹³ Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
¹⁴ Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
¹⁵ Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan.
¹⁶ Graduate Institute of Biomedical Science, China Medical University College of Medicine, Taichung, Taiwan.
¹⁷ Department of Health Services Administration, China Medical University College of Public Health, Taichung, Taiwan.
¹⁸ Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan.

PMID: 36701340
PMCID: PMC9879419
DOI: 10.1371/journal.pone.0269096

Renal function is associated with one-month and one-year mortality in patients with intracerebral hemorrhage

I-Kuan Wang et al. PLoS One. 2023.

. 2023 Jan 26;18(1):e0269096.

doi: 10.1371/journal.pone.0269096. eCollection 2023.

Authors

Affiliations

¹ Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
² Division of Nephrology, China Medical University Hospital, Taichung, Taiwan.
³ Division of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
⁴ Chang Gung University College of Medicine, Taoyuan, Taiwan.
⁵ Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
⁶ Neurology, En Chu Kong Hospital, New Taipei City, Taiwan.
⁷ Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁸ Department of Neurology, Show Chwan Memorial Hospital, Changhua County, Taiwan.
⁹ Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.
¹⁰ Department of Neurology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
¹¹ Division of Neurology Department of Internal Medicine, Cheng Hsin General Hospital, Taipei, Taiwan.
¹² Department of Neurology, St. Martin De Porres Hospital, Chiayi, Taiwan.
¹³ Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
¹⁴ Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
¹⁵ Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan.
¹⁶ Graduate Institute of Biomedical Science, China Medical University College of Medicine, Taichung, Taiwan.
¹⁷ Department of Health Services Administration, China Medical University College of Public Health, Taichung, Taiwan.
¹⁸ Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan.

PMID: 36701340
PMCID: PMC9879419
DOI: 10.1371/journal.pone.0269096

Abstract

Objective: This study evaluated short-term (1-month) and long-term (1-year) mortality risks associated with the glomerular filtration rate (eGFR) on admission for patients with intracerebral hemorrhage.

Methods: From the Taiwan Stroke Registry data from April 2006 to December 2016, we identified and stratified patients with intracerebral hemorrhage into five subgroups by the eGFR level on admission: ≥90, 60-89, 30-59, 15-29, and <15 mL/min/1.73 m2 or on dialysis. Risks for 1-month and 1-year mortality after intracerebral hemorrhage were compared by the eGFR levels.

Results: Both the 1-month and 1-year mortality rates progressively increased with the decrease in eGFR levels. The 1-month mortality rate in patients with eGFR < 15 mL/min/1.73 m2 or on dialysis was approximately 5.5-fold greater than that in patients with eGFR ≥ 90 mL/min/1.73 m2 (8.31 versus 1.50 per 1000 person-days), with an adjusted hazard ratio (HR) of 4.59 [95% confidence interval (CI) = 2.71-7.78]. Similarly, the 1-year mortality in patients with eGFR < 15 mL/min/1.73 m2 or on dialysis was 7.5 times that in patients with eGFR ≥ 90 mL/min/1.73 m2 (2.34 versus 0.31 per 1000 person-days), with an adjusted HR of 4.54 (95% CI 2.95-6.98).

Conclusion: Impairment of renal function is an independent risk factor for mortality in patients with intracerebral hemorrhage in a gradual way. The eGFR level is a prognostic indicator for patients with intracerebral hemorrhage.

Copyright: © 2023 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

**Fig 1. Flow chart for identifying patients with intracerebral hemorrhage by eGFR levels on admission.**

**Fig 2. The cumulative incidence of mortalities after intracerebral hemorrhagic by eGFR levels on admission.**

**Fig 3. Area under the receiver operating characteristic curves for eGFR levels on admission in predicting 1-month (A) and 1-year (B) mortality in patients with intracerebral hemorrhage.**

See this image and copyright information in PMC

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Renal function is associated with one-month and one-year mortality in patients with intracerebral hemorrhage

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Renal function is associated with one-month and one-year mortality in patients with intracerebral hemorrhage

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