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. 2023 May 1;207(9):1243-1246.
doi: 10.1164/rccm.202212-2203LE.

Ozone Reaction Products Associated with Biomarkers of Cardiorespiratory Pathophysiology

Linchen He  1   2 , Charles J Weschler  3   4 , Yinping Zhang  5   6 , Feng Li  7 , Michael H Bergin  8 , Marilyn Black  9 , Junfeng Jim Zhang  10   11   12
Affiliations

Ozone Reaction Products Associated with Biomarkers of Cardiorespiratory Pathophysiology

Linchen He et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
The percent change in adverse effects (increase or decrease) associated with a 10-ppb increase in ozone (O3) exposure (controlled for particulate matter ⩽2.5 μm in aerodynamic diameter (PM2.5) and O3 loss exposure) and a 10-ppb increase in O3 loss exposure (controlled for PM2.5 and O3 exposure) in the Children study. Only biomarkers that show a statistically significant association (P value < 0.05) with 12-hour, 24-hour (at any of lag days), or 2-week average O3 or O3 loss exposure are shown. If multiple significant or nonsignificant associations were found, the associations with the smallest P value are shown in the figure. Significant and adverse associations between biomarkers and O3 loss exposures: FeNO (fractional exhaled nitric oxide) (12-h, 24-h, lag Day 2, 2-wk), Z5 (24-h), X5 (24-h), Fres (24-h, lag Day 1), FEV1/FVC: (12-h). A positive value (y-axis) indicates an adverse effect, and a negative value indicates a beneficial effect. Fixed-effect covariates: Sex, age, ambient temperature and humidity, baseline eosinophil number (/μl), upper airway tract infection-like symptoms (binary), inhaled corticosteroid usage (binary), asthma exacerbation (binary). A sensitivity analysis for FEV1/FVC: and FeNO by adjusting for height and weight showed similar results. Participant baseline characteristics: Age (mean [SD] = 7.8 [2.3], range = 5–13, and unit = years), sex (17 males and 26 females), eosinophil count (mean [SD] = 379 [265], range = 80–1260, and unit = /μl). CI = confidence interval; Fres = resonant frequency; MDA = malondialdehyde; X5 = reactance at 5 Hz; Z5 = impedance at 5 Hz.
Figure 2.
Figure 2.
The percent change in adverse effects (increase or decrease) associated with a 10-ppb increase in ozone (O3) exposure (controlled for particulate matter ⩽2.5 μm in aerodynamic diameter (PM2.5) and O3 loss exposure) and a 10-ppb increase in O3 loss exposure (controlled for PM2.5 and O3 exposure) in the Adults study. Only biomarkers that show a statistically significant association (P value < 0.05) with 12-hour, 24-hour (at any of lag days), or 2-week average O3 or O3 loss exposure are shown. If multiple significant or nonsignificant associations were found, the associations with the smallest P value are shown in the figure. Significant and adverse associations between biomarkers and O3 loss exposures: EBC NN (nitrate and nitrite in exhaled breath condensate) (12-h, lag Day 2), FeNO (fractional exhaled nitric oxide) (lag Day 1, lag Day 2, 2-wk), 8-OHdG (8-hydroxy-2′-deoxyguanosine) (12-h, lag Day 2), 20-HETE (12-h, lag Day 1, lag Day 2, 2-wk), P-selectin (12-h, lag Day 1, lag D 2), DBP (24-h, lag Day 1, lag Day 2, 2-wk), SBP (12-h, 24-h, lag Day 1, lag Day 2, 2-wk). A positive value (y-axis) indicates an adverse effect, and a negative value indicates a beneficial effect. Fixed-effect covariates: sex, age, ambient temperature and humidity, time since last eating (h), secondhand smoke exposure (h), current smoking status (binary), urinary 6-sulfatoxymelatonin (ng/ml, as a surrogate of circulating melatonin, is adjusted when EBC NN, EBC MDA, or 8-OHdG is the health outcome). A sensitivity analysis for FeNO by adjusting for height and weight showed similar results. Participant baseline characteristics: age (mean [SD] = 31.5 [7.6], range = 22–52, and unit = years), sex (64 males and 25 females), current smoker (n = 15). 20-HETE = 20-hydroxyeicosatetraenoic acid; AI = augmentation index; CI = confidence interval; DBP = diastolic blood pressure; MDA = malondialdehyde; PWV = pulse wave velocity; SBP= systolic blood pressure; VWF = von Willebrand factor.
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