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. 2023 May 1;207(9):1243-1246.
doi: 10.1164/rccm.202212-2203LE.

Ozone Reaction Products Associated with Biomarkers of Cardiorespiratory Pathophysiology

Linchen He  1   2 , Charles J Weschler  3   4 , Yinping Zhang  5   6 , Feng Li  7 , Michael H Bergin  8 , Marilyn Black  9 , Junfeng Jim Zhang  10   11   12
Affiliations

Ozone Reaction Products Associated with Biomarkers of Cardiorespiratory Pathophysiology

Linchen He et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
The percent change in adverse effects (increase or decrease) associated with a 10-ppb increase in ozone (O3) exposure (controlled for particulate matter ⩽2.5 μm in aerodynamic diameter (PM2.5) and O3 loss exposure) and a 10-ppb increase in O3 loss exposure (controlled for PM2.5 and O3 exposure) in the Children study. Only biomarkers that show a statistically significant association (P value < 0.05) with 12-hour, 24-hour (at any of lag days), or 2-week average O3 or O3 loss exposure are shown. If multiple significant or nonsignificant associations were found, the associations with the smallest P value are shown in the figure. Significant and adverse associations between biomarkers and O3 loss exposures: FeNO (fractional exhaled nitric oxide) (12-h, 24-h, lag Day 2, 2-wk), Z5 (24-h), X5 (24-h), Fres (24-h, lag Day 1), FEV1/FVC: (12-h). A positive value (y-axis) indicates an adverse effect, and a negative value indicates a beneficial effect. Fixed-effect covariates: Sex, age, ambient temperature and humidity, baseline eosinophil number (/μl), upper airway tract infection-like symptoms (binary), inhaled corticosteroid usage (binary), asthma exacerbation (binary). A sensitivity analysis for FEV1/FVC: and FeNO by adjusting for height and weight showed similar results. Participant baseline characteristics: Age (mean [SD] = 7.8 [2.3], range = 5–13, and unit = years), sex (17 males and 26 females), eosinophil count (mean [SD] = 379 [265], range = 80–1260, and unit = /μl). CI = confidence interval; Fres = resonant frequency; MDA = malondialdehyde; X5 = reactance at 5 Hz; Z5 = impedance at 5 Hz.
Figure 2.
Figure 2.
The percent change in adverse effects (increase or decrease) associated with a 10-ppb increase in ozone (O3) exposure (controlled for particulate matter ⩽2.5 μm in aerodynamic diameter (PM2.5) and O3 loss exposure) and a 10-ppb increase in O3 loss exposure (controlled for PM2.5 and O3 exposure) in the Adults study. Only biomarkers that show a statistically significant association (P value < 0.05) with 12-hour, 24-hour (at any of lag days), or 2-week average O3 or O3 loss exposure are shown. If multiple significant or nonsignificant associations were found, the associations with the smallest P value are shown in the figure. Significant and adverse associations between biomarkers and O3 loss exposures: EBC NN (nitrate and nitrite in exhaled breath condensate) (12-h, lag Day 2), FeNO (fractional exhaled nitric oxide) (lag Day 1, lag Day 2, 2-wk), 8-OHdG (8-hydroxy-2′-deoxyguanosine) (12-h, lag Day 2), 20-HETE (12-h, lag Day 1, lag Day 2, 2-wk), P-selectin (12-h, lag Day 1, lag D 2), DBP (24-h, lag Day 1, lag Day 2, 2-wk), SBP (12-h, 24-h, lag Day 1, lag Day 2, 2-wk). A positive value (y-axis) indicates an adverse effect, and a negative value indicates a beneficial effect. Fixed-effect covariates: sex, age, ambient temperature and humidity, time since last eating (h), secondhand smoke exposure (h), current smoking status (binary), urinary 6-sulfatoxymelatonin (ng/ml, as a surrogate of circulating melatonin, is adjusted when EBC NN, EBC MDA, or 8-OHdG is the health outcome). A sensitivity analysis for FeNO by adjusting for height and weight showed similar results. Participant baseline characteristics: age (mean [SD] = 31.5 [7.6], range = 22–52, and unit = years), sex (64 males and 25 females), current smoker (n = 15). 20-HETE = 20-hydroxyeicosatetraenoic acid; AI = augmentation index; CI = confidence interval; DBP = diastolic blood pressure; MDA = malondialdehyde; PWV = pulse wave velocity; SBP= systolic blood pressure; VWF = von Willebrand factor.
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References

    1. Murray CJ, Aravkin AY, Zheng P, Abbafati C, Abbas KM, Abbasi-Kangevari M, et al. GBD 2019 Risk Factors Collaborators Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet . 2020;396:1223–1249. - PMC - PubMed
    1. Weschler CJ. Ozone’s impact on public health: contributions from indoor exposures to ozone and products of ozone-initiated chemistry. Environ Health Perspect . 2006;114:1489–1496. - PMC - PubMed
    1. Liu Y, Misztal PK, Arata C, Weschler CJ, Nazaroff WW, Goldstein AH. Observing ozone chemistry in an occupied residence. Proc Natl Acad Sci USA . 2021;118:e2018140118. - PMC - PubMed
    1. Fiedler N, Laumbach R, Kelly-McNeil K, Lioy P, Fan Z-H, Zhang J, et al. Health effects of a mixture of indoor air volatile organics, their ozone oxidation products, and stress. Environ Health Perspect . 2005;113:1542–1548. - PMC - PubMed
    1. Laumbach RJ, Fiedler N, Gardner CR, Laskin DL, Fan Z-H, Zhang J, et al. Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products. J Occup Environ Med . 2005;47:1182–1189. - PubMed

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