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Review
. 2023 Mar 14;44(11):921-930.
doi: 10.1093/eurheartj/ehac810.

Improving representativeness in trials: a call to action from the Global Cardiovascular Clinical Trialists Forum

Affiliations
Review

Improving representativeness in trials: a call to action from the Global Cardiovascular Clinical Trialists Forum

Lynaea Filbey et al. Eur Heart J. .

Abstract

Participants enrolled in cardiovascular disease (CVD) randomized controlled trials are not often representative of the population living with the disease. Older adults, children, women, Black, Indigenous and People of Color, and people living in low- and middle-income countries are typically under-enrolled in trials relative to disease distribution. Treatment effect estimates of CVD therapies have been largely derived from trial evidence generated in White men without complex comorbidities, limiting the generalizability of evidence. This review highlights barriers and facilitators of trial enrollment, temporal trends, and the rationale for representativeness. It proposes strategies to increase representativeness in CVD trials, including trial designs that minimize the research burden on participants, inclusive recruitment practices and eligibility criteria, diversification of clinical trial leadership, and research capacity-building in under-represented regions. Implementation of such strategies could generate better and more generalizable evidence to reduce knowledge gaps and position the cardiovascular trial enterprise as a vehicle to counter existing healthcare inequalities.

Keywords: Clinical trials; Equity; Health equity‌; Research equity; Trial eligibility‌; Trial representativeness; diversity; inclusion.

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Conflict of interest statement

Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. E.L. has an American Heart Association (AHA) Strategically-Focused Research Network (SFRN) grant studying diversity in clinical trials. T.P.W. is funded by the Division of Intramural Research of the National Heart, Lung, and Blood Institute and the Intramural Research Program of the National Institute on Minority Health and Health Disparities. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institute on Minority Health and Health Disparities; the National Institutes of Health; or the U.S. Department of Health and Human Services. J.M. has received grant support from the National Heart, Lung, and Blood Institute; Alliance for Health Policy and Systems Research; Bloomberg Philanthropies; FONDECYT; British Council, British Embassy and the Newton-Paulet Fund; DFID/MRC/Wellcome Global Health Trials; Fogarty International Center; Grand Challenges Canada; International Development Research Center Canada; Inter-American Institute for Global Change Research; National Cancer Institute; National Institute of Mental Health; Swiss National Science Foundation; Wellcome; and World Diabetes Foundation. The content in this manuscript represents the views of the authors and does not represent the views of the organizations that support J.M. L.Z. is funded by the South African Medical Research Council (SAMRC) through its Division of Research Capacity Development under the Mid-Career Scientist Programme from funding received from the South African National Treasury. The content hereof is the sole responsibility of the authors and does not necessarily represent the official views of the SAMRC. L.Z. also receives support from the National Research Foundation of South Africa (NRFSA), as well as the UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement, via the African Research Leader Award (MR/S005242/1).

Figures

Graphical Abstract
Graphical Abstract
Barriers to enrollment of diverse populations and strategies to achieve representative enrollment in cardiovascular clinical trials.
Figure 1
Figure 1
Benefits of representativeness in cardiovascular clinical trials.
Figure 2
Figure 2
Under-represented groups in cardiovascular randomized clinical trials.
Figure 3
Figure 3
Institutional strategies to improve representativeness in the cardiovascular trial enterprise.

References

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