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Comment
. 2023 Mar;39(3):155-157.
doi: 10.1016/j.pt.2023.01.006. Epub 2023 Jan 24.

The troubled puberty of malaria parasites

Jonas Gockel  1 , Till S Voss  2 , Richárd Bártfai  3
Affiliations
Comment

The troubled puberty of malaria parasites

Jonas Gockel et al. Trends Parasitol. 2023 Mar.

Abstract

Sexual differentiation of malaria parasites is essential for transmission, yet the underlying mechanisms are poorly understood. Russell et al. elegantly combined a loss-of-function screen with single-cell RNA-sequencing to identify key factors in this process. Gomes et al. further characterized one of them, MD1, as a regulator contributing to male fate determination.

Keywords: Plasmodium; gametocytes; malaria; sex determination; sexual differentiation; transmission.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Regulators of male and female sexual development are critical for the transmission of a malaria parasite.
    Russell AJC, Sanderson T, Bushell E, Talman AM, Anar B, Girling G, Hunziker M, Kent RS, Martin JS, Metcalf T, Montandon R, Pandey V, Pardo M, Roberts AB, Sayers C, Schwach F, Choudhary JS, Rayner JC, Voet T, Modrzynska KK, Waters AP, Lawniczak MKN, Billker O. Russell AJC, et al. Cell Host Microbe. 2023 Feb 8;31(2):305-319.e10. doi: 10.1016/j.chom.2022.12.011. Epub 2023 Jan 11. Cell Host Microbe. 2023. PMID: 36634679 Free PMC article.

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