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. 2023;21(3):243-249.
doi: 10.2174/1871525721666230126114224.

6-(Arylaminomethyl) Isoquinolines as Enzyme Inhibitors and Their Preparation: A Patent Highlight of Factor XIIa Inhibitors

Rami A Al-Horani  1
Affiliations

6-(Arylaminomethyl) Isoquinolines as Enzyme Inhibitors and Their Preparation: A Patent Highlight of Factor XIIa Inhibitors

Rami A Al-Horani. Cardiovasc Hematol Agents Med Chem. 2023.

Abstract

Keywords: Isoquinolines; anticoagulants; clotting; enzyme inhibitors; factor XIIa.

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Conflict of interest statement

CONFLICT OF INTEREST

The author declares no conflict of interest, financial or otherwise.

Figures

Fig. (1).
Fig. (1).
Key derivatives of 6-(Arylaminomethyl) Isoquinolines are claimed as FXIIa inhibitors in this patent.
See this image and copyright information in PMC

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References

    1. Ivanov I; Matafonov A; Sun M; Cheng Q; Dickeson SK; Verhamme IM; Emsley J; Gailani D Proteolytic properties of single-chain factor XII: A mechanism for triggering contact activation. Blood, 2017, 129(11), 1527–1537. 10.1182/blood-2016-10-744110 - DOI - PMC - PubMed
    1. Pathak M; Manna R; Li C; Kaira BG; Hamad BK; Belviso BD; Bonturi CR; Dreveny I; Fischer PM; Dekker LV; Oliva MLV; Emsley J Crystal structures of the recombinant β-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics. Acta Crystallogr. D Struct. Biol, 2019, 75(6), 578–591. 10.1107/S2059798319006910 - DOI - PubMed
    1. Dementiev A; Silva A; Yee C; Li Z; Flavin MT; Sham H; Partridge JR Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors. Blood Adv., 2018, 2(5), 549–558. 10.1182/bloodadvances.2018016337 - DOI - PMC - PubMed
    1. Fischer PM Design of small-molecule active-site inhibitors of the S1A family proteases as procoagulant and anticoagulant drugs. J. Med. Chem, 2018, 61(9), 3799–3822. 10.1021/acs.jmedchem.7b00772 - DOI - PubMed
    1. Hamad BK; Pathak M; Manna R; Fischer PM; Emsley J; Dekker LV Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation. J. Thromb. Haemost, 2017, 15(9), 1818–1828. 10.1111/jth.13773 - DOI - PMC - PubMed