6-(Arylaminomethyl) Isoquinolines as Enzyme Inhibitors and Their Preparation: A Patent Highlight of Factor XIIa Inhibitors
- PMID: 36703578
- PMCID: PMC10501477
- DOI: 10.2174/1871525721666230126114224
6-(Arylaminomethyl) Isoquinolines as Enzyme Inhibitors and Their Preparation: A Patent Highlight of Factor XIIa Inhibitors
Abstract
Keywords: Isoquinolines; anticoagulants; clotting; enzyme inhibitors; factor XIIa.
Conflict of interest statement
CONFLICT OF INTEREST
The author declares no conflict of interest, financial or otherwise.
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- Pathak M; Manna R; Li C; Kaira BG; Hamad BK; Belviso BD; Bonturi CR; Dreveny I; Fischer PM; Dekker LV; Oliva MLV; Emsley J Crystal structures of the recombinant β-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics. Acta Crystallogr. D Struct. Biol, 2019, 75(6), 578–591. 10.1107/S2059798319006910 - DOI - PubMed
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