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Review
. 2023 Jan 10:13:1054312.
doi: 10.3389/fphar.2022.1054312. eCollection 2022.

The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicine

Linlin Jiang  1   2 , Xuedong An  1 , Yingying Duan  1   2 , Fengmei Lian  1 , De Jin  1 , Yuehong Zhang  1 , Cunqing Yang  1 , Yuqing Zhang  1 , Xiaomin Kang  1   2 , Yuting Sun  1
Affiliations
Review

The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicine

Linlin Jiang et al. Front Pharmacol. .

Abstract

The severe acute respiratory syndrome coronavirus - 2 (SARS - CoV - 2) was reported to cause the Wuhan outbreak of the corona virus disease 2019(COVID-19). To date, the COVID-19 has infected more than 600 million people gloabally. As a growing number of patients recover from acute infections and are discharged from hospitals, the proportion of patients in the recovery period is gradually increasing. Many of these individuals have been reported to experience multiple symptoms during the convalescence, such as fatigue, dyspnea and pain which are designated as "long-COVID", "post-COVID syndrome" or "recovery sequelae. We searched for recent articles published in PubMed on COVID-19 convalescence and found that the pathogenesis of COVID-19 convalescence is not yet well recognized. It may be associated with incomplete recovery of immune system, parenchymal organ damage (liver or lung), coagulation abnormalities, "second hit" caused by viral infection, and Phenomenon of Cell Senescence-Associated Secretory Phenotype (SASP). Some drugs and psychological factors of patients also play a non-negligible role in it. We also found that the effect of traditional Chinese medicine (TCM) is effective in the treatment of the COVID-19 recovery phase, which can not only relieve the corresponding symptoms, but also improve the indicators and pulmonary fibrosis. Bufei Huoxue Capsule, as the only drug explicitly mentioned for COVID-19 recovery period, can exert strong rehabilitative effects on physiological activity in patients recovering from COVID-19. In addition, in previous studies, traditional Chinese medicine has been confirmed to have the ability to resist cytokine storms, as well as improve coagulation and myocardial damage, which makes it have potential therapeutic advantages in targeting the hyperimmune response, coagulation abnormalities and myocardial damage existing in the recovery period. In conclusion, the clinical symptoms of patients convalescing from COVID-19 are complex, and its pathogenesis has not been elucidated. traditional Chinese medicine, as a traditional treatment, its specific action and mechanism need to be confirmed by more studies, so that it can play a better role.

Keywords: COVID-19; TCM (trad. Chinese medicine); long-COVID-19; mechanism; recovery period.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
COVID-19 systemic symptom chart.
FIGURE 2
FIGURE 2
COVID-19 Mechanical map.
See this image and copyright information in PMC

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References

    1. Ahmad J., Barnhart H. X., Bonacini M., Ghabril M., Hayashi P. H., Odin J. A., et al. (2022). Value of liver biopsy in the diagnosis of drug-induced liver injury. J. Hepatol. 76, 1070–1078. 10.1016/j.jhep.2021.12.043 - DOI - PMC - PubMed
    1. Ali L., Naeem M., Canibano B., John A., Iqrar A. (2021). Bilateral acute optic perineuritis associated with COVID-19 in a patient with seronegative myelin oligodendrocyte glycoprotein (MOG) antibody. Cureus 13, e18234. 10.7759/cureus.18234 - DOI - PMC - PubMed
    1. Ali N. (2020). Relationship between COVID-19 infection and liver injury: A review of recent data. Front. Med. (Lausanne) 7, 458. 10.3389/fmed.2020.00458 - DOI - PMC - PubMed
    1. Alvarez A., Amirianfar E., Mason M. C., Huang L., Jose J., Tiu T. (2021). Extended neuralgic amyotrophy syndrome in a confirmed COVID-19 patient after intensive care unit and inpatient rehabilitation stay. Am. J. Phys. Med. Rehabil. 100, 733–736. 10.1097/PHM.0000000000001795 - DOI - PubMed
    1. Alwan N. A. (2021). The road to addressing Long Covid. Science 373, 491–493. 10.1126/science.abg7113 - DOI - PubMed