Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis
- PMID: 36703748
- PMCID: PMC9872944
- DOI: 10.3389/fphar.2022.1094405
Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis
Abstract
Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects. Studies have found that G. lucidum has pharmacological effects such as antioxidant, antitumor, anti-aging, anti-liver fibrosis, and immunomodulation. The main active components of G. lucidum include triterpenoids, polysaccharides, sterols, peptides and other bioactive components. Among them, the triterpenoids and polysaccharide components of G. lucidum have a wide range of anti-liver fibrotic effects. Currently, there have been more reviews and studies on the antioxidant, antitumor, and anti-aging properties of G. lucidum. Based on the current trend of increasing number of liver fibrosis patients in the world, we summarized the role of G.lucidum extract in anti-liver fibrosis and the effect of G. lucidum extract on liver fibrosis induced by different pathogenesis, which were discussed and analyzed. Research and development ideas and references are provided for the subsequent application of G. lucidum extracts in anti-liver fibrosis treatment.
Keywords: Ganoderma lucidum; chromatography; liver fibrosis; pharmacology; polysaccharide; triterpenes.
Copyright © 2023 Peng, Zhong, Cheng, Chen, Tong, Shi and Bai.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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