Inhibition of galectins in cancer: Biological challenges for their clinical application
- PMID: 36703969
- PMCID: PMC9872792
- DOI: 10.3389/fimmu.2022.1104625
Inhibition of galectins in cancer: Biological challenges for their clinical application
Abstract
Galectins play relevant roles in tumor development, progression and metastasis. Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To date, however, clinical trials based on galectin inhibitors reported inconclusive results. This review summarizes the galectin inhibitors currently being evaluated and discusses some of the biological challenges that need to be addressed to improve these strategies for the benefit of cancer patients.
Keywords: cancer treatments; galectin inhibitors; galectins; medical intervention for cancer; tumor microenvironment.
Copyright © 2023 Laderach and Compagno.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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