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Review
. 2023 Jan 10:13:1104625.
doi: 10.3389/fimmu.2022.1104625. eCollection 2022.

Inhibition of galectins in cancer: Biological challenges for their clinical application

Diego José Laderach  1   2   3 , Daniel Compagno  1   2
Affiliations
Review

Inhibition of galectins in cancer: Biological challenges for their clinical application

Diego José Laderach et al. Front Immunol. .

Abstract

Galectins play relevant roles in tumor development, progression and metastasis. Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To date, however, clinical trials based on galectin inhibitors reported inconclusive results. This review summarizes the galectin inhibitors currently being evaluated and discusses some of the biological challenges that need to be addressed to improve these strategies for the benefit of cancer patients.

Keywords: cancer treatments; galectin inhibitors; galectins; medical intervention for cancer; tumor microenvironment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Galectin inhibitory strategies.
See this image and copyright information in PMC

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