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Comparative Study
. 1987 Nov;330(6144):132-7.
doi: 10.1038/330132a0.

cDNA sequence of human apolipoprotein(a) is homologous to plasminogen

J W McLean  1 , J E Tomlinson, W J Kuang, D L Eaton, E Y Chen, G M Fless, A M Scanu, R M Lawn
Affiliations
Comparative Study

cDNA sequence of human apolipoprotein(a) is homologous to plasminogen

J W McLean et al. Nature. 1987 Nov.

Abstract

Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.

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