Single cell RNA sequencing research in maternal fetal interface

doi:10.3389/fcell.2022.1079961

Review

. 2023 Jan 10:10:1079961.

doi: 10.3389/fcell.2022.1079961. eCollection 2022.

Single cell RNA sequencing research in maternal fetal interface

Qian Chen^{1

2}, Dan Shan^{1

2}, Yupei Xie^{1

2}, Xingrong Luo^{1

2}, Yuxia Wu^{1

2}, Qiuhe Chen^{1

2}, Ruihong Dong^{1

2}, Yayi Hu^{1

2

3}

Affiliations

¹ Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China.
² Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
³ Qingbaijiang Maternal and Child Health Hospital, Chengdu, China.

PMID: 36704195
PMCID: PMC9871254
DOI: 10.3389/fcell.2022.1079961

Review

Single cell RNA sequencing research in maternal fetal interface

Qian Chen et al. Front Cell Dev Biol. 2023.

. 2023 Jan 10:10:1079961.

doi: 10.3389/fcell.2022.1079961. eCollection 2022.

Authors

Qian Chen^{1

2}, Dan Shan^{1

2}, Yupei Xie^{1

2}, Xingrong Luo^{1

2}, Yuxia Wu^{1

2}, Qiuhe Chen^{1

2}, Ruihong Dong^{1

2}, Yayi Hu^{1

2

3}

Affiliations

¹ Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China.
² Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
³ Qingbaijiang Maternal and Child Health Hospital, Chengdu, China.

PMID: 36704195
PMCID: PMC9871254
DOI: 10.3389/fcell.2022.1079961

Abstract

The maternal-fetal interface is an essential environment for embryonic growth and development, and a successful pregnancy depends on the dynamic balance of the microenvironment at the maternal-fetal interface. Single-cell sequencing, which unlike bulk sequencing that provides averaged data, is a robust method for interpreting the cellular and molecular landscape at single-cell resolution. With the support of single-cell sequencing, the issue of maternal-fetal interface heterogeneity during pregnancy has been more deeply elaborated and understood, which is important for a deeper understanding of physiological and pathological pregnancy. In this paper, we analyze the recent studies of single-cell transcriptomics in the maternal-fetal interface, and provide new directions for understanding and treating various pathological pregnancies.

Keywords: NK cells; T cells; decidual stromal cells; macrophages; maternal-fetal interface; single-cell RNA sequencing; trophoblast cell.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

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[1] Abrahams V. M., Kim Y. M., Straszewski S. L., Romero R., Mor G. (2004). Macrophages and apoptotic cell clearance during pregnancy. Am. J. Reprod. Immunol. 51 (4), 275–282. 10.1111/j.1600-0897.2004.00156.x - DOI - PubMed

[2] Abrahams V. M., Kim Y. M., Straszewski S. L., Romero R., Mor G. (2004). Macrophages and apoptotic cell clearance during pregnancy. Am. J. Reprod. Immunol. 51 (4), 275–282. 10.1111/j.1600-0897.2004.00156.x - DOI - PubMed

[3] Ander S. E., Diamond M. S., Coyne C. B. (2019). Immune responses at the maternal-fetal interface. Sci. Immunol. 4 (31), eaat6114. 10.1126/sciimmunol.aat6114 - DOI - PMC - PubMed

[4] Ander S. E., Diamond M. S., Coyne C. B. (2019). Immune responses at the maternal-fetal interface. Sci. Immunol. 4 (31), eaat6114. 10.1126/sciimmunol.aat6114 - DOI - PMC - PubMed

[5] Armand E. J., Li J., Xie F., Luo C., Mukamel E. A. (2021). Single-cell sequencing of brain cell transcriptomes and epigenomes. Neuron 109 (1), 11–26. 10.1016/j.neuron.2020.12.010 - DOI - PMC - PubMed

[6] Armand E. J., Li J., Xie F., Luo C., Mukamel E. A. (2021). Single-cell sequencing of brain cell transcriptomes and epigenomes. Neuron 109 (1), 11–26. 10.1016/j.neuron.2020.12.010 - DOI - PMC - PubMed

[7] Baslan T., Hicks J. (2017). Unravelling biology and shifting paradigms in cancer with single-cell sequencing. Nat. Rev. Cancer 17 (9), 557–569. 10.1038/nrc.2017.58 - DOI - PubMed

[8] Baslan T., Hicks J. (2017). Unravelling biology and shifting paradigms in cancer with single-cell sequencing. Nat. Rev. Cancer 17 (9), 557–569. 10.1038/nrc.2017.58 - DOI - PubMed

[9] Blom A. M. (2017). The role of complement inhibitors beyond controlling inflammation. J. Intern Med. 282 (2), 116–128. 10.1111/joim.12606 - DOI - PubMed

[10] Blom A. M. (2017). The role of complement inhibitors beyond controlling inflammation. J. Intern Med. 282 (2), 116–128. 10.1111/joim.12606 - DOI - PubMed

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Single cell RNA sequencing research in maternal fetal interface

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Single cell RNA sequencing research in maternal fetal interface

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