Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan 10:10:1103785.
doi: 10.3389/fbioe.2022.1103785. eCollection 2022.

Advances in the application of Raman spectroscopy in haematological tumours

Haoyue Liang  1 , Ruxue Shi  2 , Haoyu Wang  1 , Yuan Zhou  1
Affiliations
Review

Advances in the application of Raman spectroscopy in haematological tumours

Haoyue Liang et al. Front Bioeng Biotechnol. .

Abstract

Hematologic malignancies are a diverse collection of cancers that affect the blood, bone marrow, and organs. They have a very unpredictable prognosis and recur after treatment. Leukemia, lymphoma, and myeloma are the most prevalent symptoms. Despite advancements in chemotherapy and supportive care, the incidence rate and mortality of patients with hematological malignancies remain high. Additionally, there are issues with the clinical diagnosis because several hematological malignancies lack defined, systematic diagnostic criteria. This work provided an overview of the fundamentals, benefits, and limitations of Raman spectroscopy and its use in hematological cancers. The alterations of trace substances can be recognized using Raman spectroscopy. High sensitivity, non-destructive, quick, real-time, and other attributes define it. Clinicians must promptly identify disorders and keep track of analytes in biological fluids. For instance, surface-enhanced Raman spectroscopy is employed in diagnosing gene mutations in myelodysplastic syndromes due to its high sensitivity and multiple detection benefits. Serum indicators for multiple myeloma have been routinely used for detection. The simultaneous observation of DNA strand modifications and the production of new molecular bonds by tip-enhanced Raman spectroscopy is of tremendous significance for diagnosing lymphoma and multiple myeloma with unidentified diagnostic criteria.

Keywords: Raman spectroscopy; haematological tumours; leukaemia; lymphoma; multiple myeloma; myelodysplastic syndromes.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Application of Raman spectroscopy in drug tracking, biomarker detection, and cell engineering (Agrawal and Samal, 2018).
FIGURE 2
FIGURE 2
The combination of nanoantenna and cancer cells inhibits proliferation (Agrawal and Samal, 2018).
FIGURE 3
FIGURE 3
CAR-T-cell therapy in cancer treatment (Zhang et al., 2022).
FIGURE 4
FIGURE 4
The process of Raman living cell sorting (Wang et al., 2017).
FIGURE 5
FIGURE 5
Application of surface-enhanced Raman spectroscopy in biology (Zong et al., 2018).
FIGURE 6
FIGURE 6
Single-cell Raman imaging technology for detecting the microenvironment of disease-related proteins, nucleic acids, and small molecules (Lin et al., 2021).
FIGURE 7
FIGURE 7
Application of nanoparticles in immunotherapy (Shi and Lammers, 2019).
FIGURE 8
FIGURE 8
Anti-cancer immune reaction process (Shi and Lammers, 2019).
FIGURE 9
FIGURE 9
Nanodrugs act on cytotoxic T cells (Shi and Lammers, 2019).
FIGURE 10
FIGURE 10
Application of surface-enhanced Raman spectroscopy in biomarker detection (Lenzi et al., 2019).
See this image and copyright information in PMC

References

    1. Agrawal G., Samal S. K. (2018). Raman spectroscopy for advanced polymeric biomaterials. ACS Biomater. Sci. Eng. 4, 1285–1299. 10.1021/acsbiomaterials.8b00258 - DOI - PubMed
    1. Agsalda-Garcia M., Shieh T., Souza R., Kamada N., Loi N., Oda R., et al. (2020). Raman-enhanced spectroscopy (RESpect) probe for childhood non-Hodgkin lymphoma. SciMed J. 2, 1–7. 10.28991/scimedj-2020-0201-1 - DOI - PMC - PubMed
    1. Alattar N., Daud H., Al-Majmaie R., Zeulla D., Al-Rubeai M., Rice J. H. (2018). Surface-enhanced Raman scattering for rapid hematopoietic stem cell differentiation analysis. Appl. Opt. 57, E184–E189. 10.1364/AO.57.00E184 - DOI - PubMed
    1. Amini H., Ban Ž., Ferger M., Lorenzen S., Rauch F., Friedrich A., et al. (2020). Tetracationic Bis-Triarylborane 1, 3-Butadiyne as a combined fluorimetric and Raman probe for simultaneous and selective sensing of various DNA, RNA, and proteins. Chemistry 26, 6017–6028. 10.1002/chem.201905328 - DOI - PMC - PubMed
    1. Auberger P., Tamburini-Bonnefoy J., Puissant A. (2020). Drug resistance in hematological malignancies. Int. J. Mol. Sci. 21, 6091. 10.3390/ijms21176091 - DOI - PMC - PubMed

LinkOut - more resources