Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan 10:10:1122619.
doi: 10.3389/fbioe.2022.1122619. eCollection 2022.

Targeting and functional effects of biomaterials-based nanoagents for acute pancreatitis treatment

Yujie Cai  1 , Qian Cao  2 , Jiannan Li  1 , Tongjun Liu  1
Affiliations
Review

Targeting and functional effects of biomaterials-based nanoagents for acute pancreatitis treatment

Yujie Cai et al. Front Bioeng Biotechnol. .

Abstract

Acute pancreatitis (AP) is a severe life-threatening inflammatory disease showing primary characteristics of excessive inflammatory response and oxidative stress. Based on the pathophysiology of AP, several anti-inflammatory and anti-oxidative stress agents have been studied. However, the low accumulated concentrations and scattered biodistributions limit the application of these agents. With the development of nanotechnology, functional nanomaterials can improve the bioavailability of drugs and extend their half-life by reducing immunogenicity to achieve targeted drug delivery. The biomaterial-based carriers can mediate the passive or active delivery of drugs to the target site for improved therapeutic effects, such as anti-oxidation and anti-inflammation for AP treatment. Other biomaterials-based nanomedicine may exhibit different functions with/without targeting effects. In this review, we have summarized the targeting and functional effects of biomaterials-based nanoagents specifically for AP treatment.

Keywords: active targeting; acute pancreatitis; biomaterials; nanotechnology; passive targeting.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer XW declared a shared parent affiliation with the authors to the handling editor at the time of review.

Figures

FIGURE 1
FIGURE 1
Targeting and functional effects of biomaterials-based nanoagents constructed specifically for AP treatment.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Anchi P., Khurana A., Swain D., Samanthula G., Godugu C. (2018). Sustained-release curcumin microparticles for effective prophylactic treatment of exocrine dysfunction of pancreas: A preclinical study on cerulein-induced acute pancreatitis. J. Pharm. Sci. 107 (11), 2869–2882. 10.1016/j.xphs.2018.07.009 - DOI - PubMed
    1. Atiyah N. A., Albayati T. M., Atiya M. A. (2022). Interaction behavior of curcumin encapsulated onto functionalized sba-15 as an efficient carrier and release in drug delivery. J. Mol. Struct. 1260, 132879. 10.1016/j.molstruc.2022.132879 - DOI
    1. Attia M. F., Anton N., Wallyn J., Omran Z., Vandamme T. F. (2019). An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites. J. Pharm. Pharmacol. 71 (8), 1185–1198. 10.1111/jphp.13098 - DOI - PubMed
    1. Bose R. J. C., Kim B. J., Arai Y., Han I-b., Moon J. J., Paulmurugan R., et al. (2018). Bioengineered stem cell membrane functionalized nanocarriers for therapeutic targeting of severe hindlimb ischemia. Biomaterials 185, 360–370. 10.1016/j.biomaterials.2018.08.018 - DOI - PubMed
    1. Carrasco C., Beatriz Rodriguez A., Pariente J. A. (2014). Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats. Hepatobiliary Pancreat. Dis. Int. 13 (4), 442–446. 10.1016/s1499-3872(14)60271-x - DOI - PubMed

LinkOut - more resources