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. 2023 Jan 10:9:1019180.
doi: 10.3389/fsurg.2022.1019180. eCollection 2022.

TERT genetic polymorphism rs2736100 is associated with an aggressive manifestation of papillary thyroid carcinoma

Xilin Nie  1 , Jinbiao Shang  1 , Wendong Wang  1
Affiliations

TERT genetic polymorphism rs2736100 is associated with an aggressive manifestation of papillary thyroid carcinoma

Xilin Nie et al. Front Surg. .

Abstract

Objectives: TERT rs2736100 genetic polymorphism is commonly found in human malignancies, indicating its key role in cancer cell transformation. The aim of this study is to investigate the effects of the functional TERT rs2736100 genetic polymorphism on the outcomes of papillary thyroid carcinoma (PTC) patients.

Materials and methods: We performed a retrospective study on the relationship between rs2736100 and clinicopathological outcomes of PTC in 500 patients (378 females and 122 males) aged 43.8 ± 11.4 years (range 15-74 years) with a median follow-up of 60 months (range, 1-455 months).

Results: TERT rs2736100 genetic polymorphism (TG/GG vs. TT) was significantly associated with several high-risk clinicopathological features such as tumor spread, extrathyroidal extension, central/lateral lymph node metastases, and Stage T III or IV disease. However, in Kaplan-Meier survival analyses, the rs2736100 mutation was unrelated to overall disease-free survival with a log-rank value of p > 0.05. In Cox-regression analyses, the overall survival rate of recurrence/neo-metastasis was related to a larger tumor size, younger age, and tumor spread but unrelated to the rs2736100 mutation.

Conclusions and significance: TERT rs2736100 genetic polymorphism mutation is more likely to manifest with aggressive clinicopathological characteristics but cannot worsen prognosis in PTC.

Keywords: TERT; manifestation; papillary thyroid carcinoma (PTC); polymorphism; rs2736100.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Results of Kaplan–Meier analyses of the impacts of TERT rs2736100 genetic polymorphism on (A) the recurrence-free survival of patients with PTC; (B) the neo-metastasis-free survival rates of patients with PTC, 14 patients were excluded because of having distant metastasis at initial diagnosis; (C) the overall recurrence-free (the recurrence of lymph nodes and neo-distant metastases was combined as an end-point event) survival rates of PTC.
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