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Review
. 2023 May;315(1):71-78.
doi: 10.1111/imr.13189. Epub 2023 Jan 27.

Layered origins of lymphoid tissue inducer cells

Serge A van de Pavert  1
Affiliations
Review

Layered origins of lymphoid tissue inducer cells

Serge A van de Pavert. Immunol Rev. 2023 May.

Abstract

The Innate Lymphoid Cell (ILC) family is a relatively recently described immune cell family involved in innate immune responses and tissue homeostasis. Lymphoid Tissue Inducer (LTi) cells are part of the type 3 (ILC3) family. The ILC3 family is the main ILC population within the embryo, in which the LTi cells are critically associated with embryonic lymph node formation. Recent studies have shown more insights in ILC origin and residency from local embryonic and tissue resident precursors. Embryonic LTi cells originating from a different hemogenic endothelial source were shown to be replaced by HSC derived progenitors in adult. This review will discuss the layered origin of the ILC3 family with an emphasis on the LTi cell lineage.

Keywords: ILC; aorta-gonad-mesonephros; fate-mapping; hematopoiesis; hemogenic endothelium; innate lymphoid cells; yolk-sac.

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References

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