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. 2023 Jun;111(6):1182-1196.
doi: 10.1002/jbm.b.35224. Epub 2023 Jan 27.

Surface and mechanical properties of polyurethane central venous catheters after repeated contact with chemotherapy excipient solutions

Afif Khzam  1 , Johanna Saunier  1 , Léa Carpentier  2 , Agnès Mignot  2 , Lionel Tortolano  1   3 , Najet Yagoubi  1
Affiliations

Surface and mechanical properties of polyurethane central venous catheters after repeated contact with chemotherapy excipient solutions

Afif Khzam et al. J Biomed Mater Res B Appl Biomater. 2023 Jun.

Abstract

This article investigates the impact of the interactions between polyurethane central venous catheters and solutions containing excipients used in cisplatin and paclitaxel formulations. Changes to the properties of catheters and the leaching of catheter additives into the infused solutions were studied while these solutions were infused cyclically for several months. Chemotherapy treatment was mimicked in vitro in compliance with hospital practices. The treatment cycle was repeated 10 times, using solutions containing only the excipients. After 10 treatment cycles, no physical or chemical degradation of the catheter was observed. Mechanical performances were stable, but surface modifications occurred, causing the surface to become more hydrophobic. A loss in polyurethane antioxidant amount was observed in part due to a leaching phenomenon.

Keywords: central venous catheter; chemotherapy; excipients; leachables; mechanical properties; surface.

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References

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