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. 2023 Jan 10:14:971220.
doi: 10.3389/fnagi.2022.971220. eCollection 2022.

Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study

Lisa Perus  1   2   3   4 , Jean-François Mangin  4   5 , Jérémy Deverdun  3 , Laure-Anne Gutierrez  2 , Emmanuelle Gourieux  4 , Clara Fischer  4 , Liesjet E H Van Dokkum  3 , Clara Manesco  6 , Germain Busto  1   2 , Sophie Guyonnet  7   8 , Bruno Vellas  7   8 , Audrey Gabelle  1   2 , Emmanuelle Le Bars  3 ; MAPT/DSA group
Collaborators, Affiliations

Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study

Lisa Perus et al. Front Aging Neurosci. .

Abstract

Introduction: The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood and may involve brain reserve and adaptability of brain functional connectivity (FC).

Methods: To determine the effect of multidomain interventions (involving physical activity, cognitive training, nutritional counseling alone or in combination with omega-3 fatty acid supplementation and vs. a placebo) on the brain, longitudinal FC changes were assessed after 36 months of intervention on 100 older adults (above 70 year-old) with subjective cognitive complaints.

Results: No global change in FC was detected after uni or multidomain preventive interventions. However, an effect of omega-3 fatty acid supplementation dependent on cognitive decline status was underlined for frontoparietal, salience, visual and sensorimotor networks FC. These findings were independent of the cortical thickness and vascular burden.

Discussion: These results emphasize the importance of patient stratification, based on risk factors, for preventive interventions.

Keywords: cognitive training; exercise; magnetic resonance imaging (MRI); multidomain intervention; omega-3 fatty acids; resting-state functional MRI (rs-fMRI).

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Conflict of interest statement

BV reports grants from Pierre Fabre, Avid, Exonhit, AbbVie, Lilly, Lundbeck, MSD, Otsuka, Regenron, Sanofi, Roche, AstraZeneca, LPG Systems, Nestlé, and Alzheon, and personal fees from Lilly, Lundbeck, MSD, Otsuka, Roche, Sanofi, Biogen, Nestlé, Transition Therapeutics, and Takeda. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Chart of participants exclusion process.
Figure 2
Figure 2
Connections showing a difference over the evolution of FC between interventions within each subgroup of baseline CDR0 and CDR0.5 (Table 3). Almost all connections were significant except for the L/R MFG/MSFG - L/R SMG/Post CG connection for the comparison CDR0.5 Om3 > Pl that was close to significance (p < 0.06)*. Om3 + MI, Omega-3 fatty acid supplementation and multidomain intervention; Om3, omega-3 fatty acid supplementation; MI, multidomain intervention; Pl, placebo; L/R Cun/SOG, left/right cuneus/superior occipital gyrus (visual network); L/R MFG/MSFG, left/right middle frontal gyrus/superior frontal gyrus medial segment (frontoparietal network); L/R SMG/Post CG, left/right supramarginal gyrus/post central gyrus (salience network); L/R MFG/SMG, left/right middle frontal gyrus/supramarginal gyrus (frontoparietal network); L/R Pre CG, left/right pre central gyrus (sensorimotor network); L/R Sup Pre/Post CG, left/right superior pre/post central gyrus (sensorimotor network); L/R Pre/Post CG, left/right pre/post central gyrus (sensorimotor network); L/R SPL, left/right superior parietal lobule (salience network); T, t-value for post hoc tests (Table 3), red connections represent a positive difference between mean connectivity of interventions group with omega-3 fatty acid supplementation vs. no omega-3 fatty acid supplementation, blue connections represent a negative difference.
See this image and copyright information in PMC

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