doi: 10.1016/0028-3908(87)90113-4.
Changes in the activity of GAD in the basal ganglia of the rat after striatal dopaminergic denervation
Affiliations
- PMID: 3670565
- DOI: 10.1016/0028-3908(87)90113-4
Item in Clipboard
Changes in the activity of GAD in the basal ganglia of the rat after striatal dopaminergic denervation
Neuropharmacology.
1987 Sep.
Abstract
The aim of this experiment was to study the effect of a unilateral lesion of the dopamine-containing nigro-striatal pathway, on the activity of glutamic acid decarboxilase (GAD) in different structures at two survival times: 4 and 8 weeks. The structures studied were the striatum and its output target areas, globus pallidus, entopeduncular nucleus and substantia nigra. Four weeks after the lesion, GAD activity was increased in the ipsilateral striatum, globus pallidus and substantia nigra. This effect was reversed at 8 weeks, when a decrease in enzyme activity was observed. These time related changes in enzyme activity reveal the presence of a physiological compensatory process.
Similar articles
-
Lesions of the globus pallidus, entopeduncular nucleus and substantia nigra alter dopamine mediated circling behaviour.Exp Brain Res. 1983;52(2):281-92. doi: 10.1007/BF00236638. Exp Brain Res. 1983. PMID: 6641888
-
Levodopa replacement therapy alters enzyme activities in striatum and neuropeptide content in striatal output regions of 6-hydroxydopamine lesioned rats.Brain Res. 1991 Jun 21;552(1):113-8. doi: 10.1016/0006-8993(91)90667-k. Brain Res. 1991. PMID: 1717109
-
Effects of nigrostriatal lesions on the levels of messenger RNAs encoding two isoforms of glutamate decarboxylase in the globus pallidus and entopeduncular nucleus of the rat.Synapse. 1992 Jun;11(2):124-33. doi: 10.1002/syn.890110205. Synapse. 1992. PMID: 1626311
-
Role of GABA in the striatal output system: globus pallidus, nucleus entopeduncularis, substantia nigra and nucleus subthalamicus.Adv Biochem Psychopharmacol. 1981;30:165-86. Adv Biochem Psychopharmacol. 1981. PMID: 7036675 Review. No abstract available.
-
The neostriatal mosaic: multiple levels of compartmental organization.Trends Neurosci. 1992 Apr;15(4):133-9. doi: 10.1016/0166-2236(92)90355-c. Trends Neurosci. 1992. PMID: 1374971 Review.
Cited by
-
Topographic distribution of dopamine uptake, choline uptake, choline acetyltransferase, and GABA uptake in the striata of weaver mutant mice.Neurochem Res. 1992 May;17(5):431-6. doi: 10.1007/BF00969888. Neurochem Res. 1992. PMID: 1528352
-
Methylazoxymethanol (MAM)-induced brain lesion and oral dyskinesia in rats.Psychopharmacology (Berl). 1990;100(1):72-6. doi: 10.1007/BF02245793. Psychopharmacology (Berl). 1990. PMID: 2296629
-
Morphological changes in the rat neostriatum after unilateral 6-hydroxydopamine injections into the nigrostriatal pathway.Exp Brain Res. 1993;93(1):17-27. doi: 10.1007/BF00227776. Exp Brain Res. 1993. PMID: 7682182
-
Intrastriatal mesencephalic grafts affect neuronal activity in basal ganglia nuclei and their target structures in a rat model of Parkinson's disease.J Neurosci. 1998 Mar 1;18(5):1806-17. doi: 10.1523/JNEUROSCI.18-05-01806.1998. J Neurosci. 1998. PMID: 9465005 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical