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. 2023 Apr 1;76(4):480-482.
doi: 10.1097/MPG.0000000000003723. Epub 2023 Jan 25.

No Increased Risk of Taking Additional Intestinal Mucosal Research Biopsies From the Duodenum During Pediatric Endoscopy

Tracey M DaFonte  1   2   3 , Elizabeth Gleeson  2   3 , Taylor Morson  2   3 , Katherine L Olshan  1   2   3 , Christopher J Moran  1 , Maureen M Leonard  1   2   3
Affiliations

No Increased Risk of Taking Additional Intestinal Mucosal Research Biopsies From the Duodenum During Pediatric Endoscopy

Tracey M DaFonte et al. J Pediatr Gastroenterol Nutr. .

Abstract

Studies involving human intestinal tissue are essential for advancing the field of celiac disease (CeD), as diagnosis requires duodenal biopsies. Performing studies in children helps to better understand CeD in this important subpopulation. This study aims to determine the risk in obtaining duodenal research biopsies during pediatric endoscopy. In this retrospective chart review from 2016 to 2022 of 1180 research subjects and controls, there were 18 procedure-related adverse events within 48 hours. Most adverse events were for symptoms of pain and fever. There was no increased risk of adverse events if additional duodenal research biopsies were taken during pediatric endoscopy.

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Conflict of interest statement

M.M.L. served on an advisory board for Mozart Therapeutics and 9Meters Biopharma and acted as a consultant for Anokion. She has served as site-PI for Takeda Pharmaceuticals. The remaining authors report no conflicts of interest.

Figures

Figure 1.
Figure 1.
The y-axis reflects the total number of procedures while the x-axis shows the number of duodenal research biopsies (range 1-5) taken in an individual patient in this study.
See this image and copyright information in PMC

References

    1. Husby S, Koletzko S, Korponay-Szabó I, et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr. 2020;70(1):141–156. - PubMed
    1. Tarar ZI, Zafar MU, Farooq U, et a. Progression of Celiac Disease, Diagnostic Modalities, and Treatment Options. J Investig Med High Impact Case Rep. 2021;9. - PMC - PubMed
    1. Yao MD, von Rosenvinge EC, Groden C, et al. Multiple endoscopic biopsies in research subjects: safety results from a National Institutes of Health series. Gastrointest Endosc 2009; 69(4): 906–910. - PMC - PubMed
    1. Hill ID, Fasano A, Guandalini S, et al. NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-related Disorders. J Pediatr Gastroenterol Nutr. 2016;63(1):156–165. - PubMed
    1. Cotton PB, Eisen GM, Aabakken L, et al. A lexicon for endoscopic adverse events: report of an ASGE workshop. Gastrointest Endosc. 2010;71(3):446–454. - PubMed

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