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Multicenter Study
. 2023 Jul;280(7):3259-3264.
doi: 10.1007/s00405-023-07855-8. Epub 2023 Jan 27.

Sensibility, specificity, and accuracy of the Sinonasal Outcome Test 8 (SNOT-8) in patients with chronic rhinosinusitis (CRS): a cross-sectional cohort study

Ignazio La Mantia  1 , Martina Ragusa  1 , Egle Grigaliute  1 , Salvatore Cocuzza  1 , Thomas Radulesco  2   3 , Christian Calvo-Henriquez  2 , Alberto Maria Saibene  2   4 , Paolo Marco Riela  5 , Jerome Rene Lechien  2   6 , Nicolas Fakhry  2   3 , Justin Michel  2   3 , Antonino Maniaci  7   8   9
Affiliations
Multicenter Study

Sensibility, specificity, and accuracy of the Sinonasal Outcome Test 8 (SNOT-8) in patients with chronic rhinosinusitis (CRS): a cross-sectional cohort study

Ignazio La Mantia et al. Eur Arch Otorhinolaryngol. 2023 Jul.

Abstract

Purpose: To analyze as the primary endpoint the accuracy, sensitivity, and specificity of the SNOT-22 assessing CRS severity and to compare the results with a version of the SNOT-8 obtained from the nasal domain items.

Methods: Data were obtained from a prospective multicenter controlled study of dupilumab in adults with moderate-severe CRSwNP. EQUATOR and STROBE network guidelines were adopted. A multivariate logistic regression model was used to evaluate the accuracy of the model with the full (SNOT-22) and reduced (SNOT-8) item set to predict the severity outcome.

Results: SNOT-22 demonstrated an AUC of 0.885 (95% CI 0.825, - 0.945), and sensitivity and specificity of 91.49% (83.92-96.25%) and 69.23% (48.21-85.67%), respectively. Interestingly, after stepwise items elimination good outcomes were reported for SNOT-8, with an AUC of 0.818 (95% CI 0.744-0.892), achieving a sensitivity of 93.51% (85.49-97.86%) and specificity of 57.14% (40.96-72.28%).

Conclusion: Psychometric analyses support the accuracy, sensitivity, and specificity of the nasal domains of SNOT-22 to assess the impact on HRQoL in patients with CRSwNP.

Keywords: Chronic rhinosinusitis with nasal polyps; HRQoL; NPS; SNOT-22.

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