Environmental risk of nontuberculous mycobacterial infection: Strategies for advancing methodology

Rachel A Mercaldo¹, Julia E Marshall², Gerard A Cangelosi³, Maura Donohue⁴, Joseph O Falkinham 3rd⁵, Noah Fierer⁶, Joshua P French⁷, Matthew J Gebert⁸, Jennifer R Honda⁹, Ettie M Lipner¹⁰, Theodore K Marras¹¹, Kozo Morimoto¹², Max Salfinger¹³, Janet Stout¹⁴, Rachel Thomson¹⁵, D Rebecca Prevots¹⁶

Affiliations

¹ Division of Intramural Research, Epidemiology and Population Studies Unit, NIAID, NIH, Rockville, MD, USA. Electronic address: rachel.mercaldo@nih.gov.
² Division of Intramural Research, Epidemiology and Population Studies Unit, NIAID, NIH, Rockville, MD, USA. Electronic address: julia.marshall@nih.gov.
³ Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address: gcang@uw.edu.
⁴ United States Environmental Protection Agency, Center for Environmental Solutions and Emergency Response, Cincinnati, OH, USA. Electronic address: donohue.maura@epa.gov.
⁵ Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA. Electronic address: jofiii@vt.edu.
⁶ Department of Ecology and Evolutionary Biology, Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO, USA. Electronic address: noah.fierer@colorado.edu.
⁷ Department of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO, USA. Electronic address: joshua.french@ucdenver.edu.
⁸ Department of Ecology and Evolutionary Biology, Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO, USA. Electronic address: matthew.gebert@colorado.edu.
⁹ Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA. Electronic address: HondaJ@njhealth.org.
¹⁰ Division of Intramural Research, Epidemiology and Population Studies Unit, NIAID, NIH, Rockville, MD, USA. Electronic address: ettie.lipner@nih.gov.
¹¹ Department of Medicine, University of Toronto and University Health Network, Toronto, Canada. Electronic address: ted.marras@uhn.ca.
¹² Division of Clinical Research, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. Electronic address: morimotok@fukujuji.org.
¹³ College of Public Health & Morsani College of Medicine, University of South Florida, Tampa, FL, USA. Electronic address: max@usf.edu.
¹⁴ Special Pathogens Laboratory, Pittsburgh, PA, USA; Department of Civil and Environmental Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: jstout@specialpathogenslab.com.
¹⁵ Gallipoli Medical Research Institute & Greenslopes Clinical School, The University of Queensland, Brisbane, Australia. Electronic address: r.thomson@uq.edu.au.
¹⁶ Division of Intramural Research, Epidemiology and Population Studies Unit, NIAID, NIH, Rockville, MD, USA. Electronic address: rprevots@nih.gov.

PMID: 36706504
PMCID: PMC10023322
DOI: 10.1016/j.tube.2023.102305

Environmental risk of nontuberculous mycobacterial infection: Strategies for advancing methodology

Rachel A Mercaldo et al. Tuberculosis (Edinb). 2023 Mar.

. 2023 Mar:139:102305.

doi: 10.1016/j.tube.2023.102305. Epub 2023 Jan 10.

Authors

Affiliations

¹ Division of Intramural Research, Epidemiology and Population Studies Unit, NIAID, NIH, Rockville, MD, USA. Electronic address: rachel.mercaldo@nih.gov.
² Division of Intramural Research, Epidemiology and Population Studies Unit, NIAID, NIH, Rockville, MD, USA. Electronic address: julia.marshall@nih.gov.
³ Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address: gcang@uw.edu.
⁴ United States Environmental Protection Agency, Center for Environmental Solutions and Emergency Response, Cincinnati, OH, USA. Electronic address: donohue.maura@epa.gov.
⁵ Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA. Electronic address: jofiii@vt.edu.
⁶ Department of Ecology and Evolutionary Biology, Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO, USA. Electronic address: noah.fierer@colorado.edu.
⁷ Department of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO, USA. Electronic address: joshua.french@ucdenver.edu.
⁸ Department of Ecology and Evolutionary Biology, Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO, USA. Electronic address: matthew.gebert@colorado.edu.
⁹ Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA. Electronic address: HondaJ@njhealth.org.
¹⁰ Division of Intramural Research, Epidemiology and Population Studies Unit, NIAID, NIH, Rockville, MD, USA. Electronic address: ettie.lipner@nih.gov.
¹¹ Department of Medicine, University of Toronto and University Health Network, Toronto, Canada. Electronic address: ted.marras@uhn.ca.
¹² Division of Clinical Research, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. Electronic address: morimotok@fukujuji.org.
¹³ College of Public Health & Morsani College of Medicine, University of South Florida, Tampa, FL, USA. Electronic address: max@usf.edu.
¹⁴ Special Pathogens Laboratory, Pittsburgh, PA, USA; Department of Civil and Environmental Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: jstout@specialpathogenslab.com.
¹⁵ Gallipoli Medical Research Institute & Greenslopes Clinical School, The University of Queensland, Brisbane, Australia. Electronic address: r.thomson@uq.edu.au.
¹⁶ Division of Intramural Research, Epidemiology and Population Studies Unit, NIAID, NIH, Rockville, MD, USA. Electronic address: rprevots@nih.gov.

PMID: 36706504
PMCID: PMC10023322
DOI: 10.1016/j.tube.2023.102305

Abstract

The National Institute of Allergy and Infectious Diseases organized a symposium in June 2022, to facilitate discussion of the environmental risks for nontuberculous mycobacteria exposure and disease. The expert researchers presented recent studies and identified numerous research gaps. This report summarizes the discussion and identifies six major areas of future research related to culture-based and culture independent laboratory methods, alternate culture media and culturing conditions, frameworks for standardized laboratory methods, improved environmental sampling strategies, validation of exposure measures, and availability of high-quality spatiotemporal data.

Published by Elsevier Ltd.

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Figures

**Figure 1:**
Nontuberculous mycobacteria case reporting in the United States. Fourteen states have some form of NTM reporting (CO, CT, LA, MD, ME, MN, MO, MS, NE, OR, TN, UT, VA, WI), including two where pulmonary and extrapulmonary NTM infection is a reportable condition (MN, CO). In addition, four states have extrapulmonary NTM infection only (MD, NE, OR, TN), and eight have NTM infection type not specified, e.g., specimen type or NTM species may not be reported (CT, LA, ME, MO, MS, UT, VA, WI). In MN and CO, Pulmonary NTM infection is reportable only in some counties.

See this image and copyright information in PMC

References

1. Floto RA, et al. , US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis. Thorax, 2016. 71 Suppl 1: p. i1–22. - PMC - PubMed
1. Adjemian J, Olivier KN, and Prevots DR, Epidemiology of Pulmonary Nontuberculous Mycobacterial Sputum Positivity in Patients with Cystic Fibrosis in the United States, 2010-2014. Ann Am Thorac Soc, 2018. 15(7): p. 817–826. - PMC - PubMed
1. Adjemian J, Olivier KN, and Prevots DR, Nontuberculous mycobacteria among patients with cystic fibrosis in the United States: screening practices and environmental risk. Am J Respir Crit Care Med, 2014. 190(5): p. 581–6. - PMC - PubMed
1. Adjemian J, et al. , Spatial clusters of nontuberculous mycobacterial lung disease in the United States. Am J Respir Crit Care Med, 2012. 186(6): p. 553–8. - PMC - PubMed
1. Adjemian J, et al. , Prevalence of nontuberculous mycobacterial lung disease in U.S. Medicare beneficiaries. Am J Respir Crit Care Med, 2012. 185(8): p. 881–6. - PMC - PubMed

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Environmental risk of nontuberculous mycobacterial infection: Strategies for advancing methodology

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Environmental risk of nontuberculous mycobacterial infection: Strategies for advancing methodology

Authors

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Medical