Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan 26;15(2):298-307.
doi: 10.18632/aging.204499. Epub 2023 Jan 26.

Are menopause, aging and prostate cancer diseases?

Mikhail V Blagosklonny  1
Affiliations

Are menopause, aging and prostate cancer diseases?

Mikhail V Blagosklonny. Aging (Albany NY). .

Abstract

There is no doubt that prostate cancer is a disease. Then, according to hyperfunction theory, menopause is also a disease. Like all age-related diseases, it is a natural process, but is also purely harmful, aimless and unintended by nature. But exactly because these diseases (menopause, prostate enlargement, obesity, atherosclerosis, hypertension, diabetes, presbyopia and thousands of others) are partially quasi-programmed, they can be delayed by slowing aging. Is aging a disease? Aging is a quasi-programmed disease that is partially treatable by rapamycin. On the other hand, aging is an abstraction, a sum of all quasi-programmed diseases and processes. In analogy, the zoo consists of animals and does not exist without animals, but the zoo is not an animal.

Keywords: geroscience; healthspan; hyperfunction theory of aging; lifespan; mTOR.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare no conflicts of interest related to this study.

References

    1. Jacklin C, Philippou Y, Brewster SF, Bryant RJ. "More men die with prostate cancer than because of it" - an old adage that still holds true in the 21st century. Cancer Treat Res Commun. 2021; 26:100225. 10.1016/j.ctarc.2020.100225 - DOI - PubMed
    1. Jahn JL, Giovannucci EL, Stampfer MJ. The high prevalence of undiagnosed prostate cancer at autopsy: implications for epidemiology and treatment of prostate cancer in the Prostate-specific Antigen-era. Int J Cancer. 2015; 137:2795–802. 10.1002/ijc.29408 - DOI - PMC - PubMed
    1. Hur J, Giovannucci E. Racial differences in prostate cancer: does timing of puberty play a role? Br J Cancer. 2020; 123:349–54. 10.1038/s41416-020-0897-4 - DOI - PMC - PubMed
    1. Bonilla C, Lewis SJ, Martin RM, Donovan JL, Hamdy FC, Neal DE, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles GG, et al., and PRACTICAL consortium. Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort. BMC Med. 2016; 14:66. 10.1186/s12916-016-0602-x - DOI - PMC - PubMed
    1. Célind J, Bygdell M, Martikainen J, Styrke J, Damber JE, Kindblom JM, Ohlsson C. Timing of the Pubertal Growth Spurt and Prostate Cancer. Cancers (Basel). 2021; 13:6238. 10.3390/cancers13246238 - DOI - PMC - PubMed