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. 2023 Jan 20;15(2):295-297.
doi: 10.18632/aging.204497. Epub 2023 Jan 20.

Pathological trajectory in the Ts65Dn model of Down syndrome

Savannah Tallino  1   2   3 , Wendy Winslow  1   3 , Ramon Velazquez  1   2   3
Affiliations

Pathological trajectory in the Ts65Dn model of Down syndrome

Savannah Tallino et al. Aging (Albany NY). .
No abstract available

Keywords: Down syndrome; Ts65Dn; amyloid-beta; cholinergic.

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Figures

Figure 1
Figure 1
The segmentally trisomic Ts65Dn mouse carries the majority of triplicated genes seen in human Down syndrome (DS) within the DS critical region (DSCR). As a result of triplication of the amyloid precursor protein within the DSCR, soluble amyloid β (Aβ) increases in the Ts65Dn mouse brain as a function of age, appearing first in the frontal cortex (FC) and hippocampus (Hp). How the time-dependent regional changes in soluble Aβ relate to the documented atrophy of basal forebrain cholinergic circuitry at 6 months is yet to be determined but may relate to endosomal alterations and/or deficient nerve growth factor (NGF) transport in these vulnerable cells. Abbreviations: MS: medial septum; CB: cerebellum; VDB: ventral diagonal band; NBM: nucleus basalis of meynert; SI: substantia innominata.
See this image and copyright information in PMC

References

    1. Martinez JL, et al.. Front Aging Neurosci. 2021; 13:703876. 10.3389/fnagi.2021.703876 - DOI - PMC - PubMed
    1. Landes SD, et al.. Disabil Health J. 2020; 13:100947. 10.1016/j.dhjo.2020.100947 - DOI - PMC - PubMed
    1. Cataldo AM, et al.. J Neurosci. 2003; 23:6788–92. 10.1523/JNEUROSCI.23-17-06788.2003 - DOI - PMC - PubMed
    1. Chen XQ, et al.. Front Neurosci. 2019; 13:446. 10.3389/fnins.2019.00446 - DOI - PMC - PubMed
    1. Davisson MT, et al.. Prog Clin Biol Res. 1993; 384:117–33. - PubMed

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