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. 2023 Apr;46(4):257-259.
doi: 10.1016/j.tins.2023.01.004. Epub 2023 Jan 26.

Invariant inhibition to calculate prediction errors?

Meaghan C Creed  1 , Michaël Loureiro  2 , Christian Lüscher  3
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Invariant inhibition to calculate prediction errors?

Meaghan C Creed et al. Trends Neurosci. 2023 Apr.

Abstract

The ventral tegmental area (VTA) has a pivotal role in motivated behavior. Much of the research on the VTA has focused on the mesocorticolimbic dopamine projections and their role in the computation of a 'reward prediction error' (RPE) for reward-guided learning. In a recent study, Zhou et al. report that VTA GABA neurons, the axons of which innervate the ventral pallidum (VP), have a unique role in signaling reward value to the basal ganglia and guiding reward seeking.

Keywords: GABA; dopamine; reward prediction error.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest in relation to this work.

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