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Review
. 2023 Apr;46(4):483-497.
doi: 10.1007/s00449-022-02842-5. Epub 2023 Jan 28.

CRISPR-Cas engineering in food science and sustainable agriculture: recent advancements and applications

Masoud Aman Mohammadi  1 , Mariana Rocha Maximiano  2   3 , Seyede Marzieh Hosseini  4 , Octavio Luiz Franco  2   3
Affiliations
Review

CRISPR-Cas engineering in food science and sustainable agriculture: recent advancements and applications

Masoud Aman Mohammadi et al. Bioprocess Biosyst Eng. 2023 Apr.

Abstract

The developments in the food supply chain to support the growing population of the world is one of today's most pressing issues, and to achieve this goal improvements should be performed in both crops and microbes. For this purpose, novel approaches such as genome editing (GE) methods have upgraded the biological sciences for genome manipulation and, among such methods, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) are the main exciting innovations since the Green Revolution. CRISPR/Cas systems can be a potent tool for the food industry, improvement of agricultural crops and even for protecting food-grade bacteria from foreign genetic invasive elements. This review introduces the history and mechanism of the CRISPR-Cas system as a genome editing tool and its applications in the vaccination of starter cultures, production of antimicrobials and bioactive compounds, and genome editing of microorganisms.

Keywords: Antimicrobial; Bacteria; CRISPR-Cas; Food safety; Genome editing.

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