Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun;50(3):173-188.
doi: 10.1007/s10928-022-09840-w. Epub 2023 Jan 27.

Computing optimal drug dosing with OptiDose: implementation in NONMEM

Freya Bachmann  1 , Gilbert Koch  2 , Robert J Bauer  3 , Britta Steffens  4 , Gabor Szinnai  5   6 , Marc Pfister  4   6 , Johannes Schropp  1
Affiliations

Computing optimal drug dosing with OptiDose: implementation in NONMEM

Freya Bachmann et al. J Pharmacokinet Pharmacodyn. 2023 Jun.

Abstract

Determining a drug dosing recommendation with a PKPD model can be a laborious and complex task. Recently, an optimal dosing algorithm (OptiDose) was developed to compute the optimal doses for any pharmacometrics/PKPD model for a given dosing scenario. In the present work, we reformulate the underlying optimal control problem and elaborate how to solve it with standard commands in the software NONMEM. To demonstrate the potential of the OptiDose implementation in NONMEM, four relevant but substantially different optimal dosing tasks are solved. In addition, the impact of different dosing scenarios as well as the choice of the therapeutic goal on the computed optimal doses are discussed.

Keywords: Dose optimization; Optimal control; Optimal dosing; Pharmacometrics; Therapeutic goal.

PubMed Disclaimer

References

    1. Gonzalez D, Rao GG, Bailey SC, Brouwer KLR, Cao Y, Crona DJ, Kashuba ADM, Lee CR, Morbitzer K, Patterson JH, Wiltshire T, Easter J, Savage SW, Powell JR (2017) Precision dosing: public health need, proposed framework, and anticipated impact. Clin Transl Sci 10(6):443–454 - DOI - PubMed - PMC
    1. Koch G, Datta AN, Jost K, Schulzke SM, van den Anker J, Pfister M (2017) Caffeine citrate dosing adjustments to assure stable caffeine concentrations in preterm neonates. J Pediatr 191:50-56.e1 - DOI - PubMed
    1. Hinze M, Pinnau R, Ulbrich M, Ulbrich S (2009) Optimization with PDE constraints. Mathematical modelling: theory and applications. Springer, Dordrecht
    1. Pontryagin LS (1987) Mathematical theory of optimal processes. Classics in Soviet mathematics. CRC Press, Boca Raton
    1. Moore H (2018) How to mathematically optimize drug regimens using optimal control. J Pharmacokinet Pharmacodyn 45:127–137 - DOI - PubMed - PMC

Publication types

LinkOut - more resources