Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan 27;16(1):24.
doi: 10.1186/s13048-022-01079-w.

How to dose follitropin delta for the first insemination cycle according to the ESHRE and ASRM guidelines; a retrospective cohort study

Suha Arab  1 , Russell Frank  2 , Jacob Ruiter  1 , Michael H Dahan  3
Affiliations

How to dose follitropin delta for the first insemination cycle according to the ESHRE and ASRM guidelines; a retrospective cohort study

Suha Arab et al. J Ovarian Res. .

Abstract

Background: Follitropin Delta (FD) is indicated exclusively for in-vitro fertilization however, being a gonadotropin it could be used for other purposes. A dosing algorithm exists for FD and IVF but is needed for intrauterine insemination (IUI) cycles. The objective of this study is to determine dosing for FD for the first controlled ovarian hyperstimulation (COH) cycle according to current stimulation guidelines.

Results: A retrospective study of 157 subjects from a single university fertility center from January 2017 to March 2020, was performed. All patients stimulated with FD for IUI were included. The number of failed, normal, or overstimulation cycles was determined based on stimulating not more than 2 mature follicles. We then stratified the group based on the AFC, AMH, and body weight. Of 157 subjects, 49% stimulated correctly, 5.6% failed and 45.4% overstimulated. An analysis of the COH IUI cycles based on stratification and over or lack of stimulation per published guidelines found that women with a bodyweight < 80 kg or AMH ≥ 1.5 ng/ml or AFC ≥ 10 initially stimulate with FD 2.0 to 3.0mcg daily. For women with an AFC of 6-9 stimulate with Follitropin Delta 3.0mcg daily. For women with an AFC < 6 or serum AMH < 1.5 ng/ml stimulate with FD 3.0-4.0mcg daily. For women with body weight > 80 kg stimulate initially with daily with 4.0-6.0mcg FD.

Conclusions: Follitropin Delta can be used safely for controlled ovarian stimulation and insemination at doses easily dispensed by the current methods of delivery, within the current published guidelines for follicle development.

Keywords: AMH; COH; Follitropin Delta; Gonadotropin; IUI; Rekovelle.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest to declare related to this article.

References

    1. Group TECW Multiple gestation pregnancy. The ESHRE Capri Workshop Group. Hum Reprod. 2000;15(8):1856–64. doi: 10.1093/humrep/15.8.1856. - DOI - PubMed
    1. Fong SA, Palta V, Oh C, Cho MM, Loughlin JS, McGovern PG. Multiple pregnancy after gonadotropin-intrauterine insemination: an unavoidable event? ISRN Obstet Gynecol. 2011;2011:465483. doi: 10.5402/2011/465483. - DOI - PMC - PubMed
    1. Use of exogenous gonadotropins for ovulation induction in anovulatory women : a committee opinion. Fertil & Steril. 2020;Jab;113(1):66–70. - PubMed
    1. Bordewijk EM, Weiss NS, Nahuis MJ, Kwee J, Lambeek AF, van Unnik GA, et al. Gonadotrophins or clomiphene citrate in women with normogonadotropic anovulation and CC failure: does the endometrium matter? Hum Reprod. 2020;35(6):1319–1324. doi: 10.1093/humrep/deaa052. - DOI - PMC - PubMed
    1. Li Q, Zhu M, Deng Z, Wang L, Huang Y, Ruan L, et al. Effect of gonadotropins and endometrial thickness on pregnancy outcome in patients with unexplained infertility or polycystic ovarian syndrome undergoing intrauterine insemination. J Int Med Res. 2020;48(10):300060520966538. doi: 10.1177/0300060520966538. - DOI - PMC - PubMed

Substances

LinkOut - more resources