Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Apr;14(4):630-631.
doi: 10.1111/jdi.13983. Epub 2023 Jan 27.

No change in small low-density lipoprotein cholesterol levels with pemafibrate might explain the negative results of the PROMINENT trial

Tsutomu Hirano  1
Affiliations
Comment

No change in small low-density lipoprotein cholesterol levels with pemafibrate might explain the negative results of the PROMINENT trial

Tsutomu Hirano. J Diabetes Investig. 2023 Apr.
No abstract available

PubMed Disclaimer

Comment on

  • Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
    Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Das Pradhan A, et al. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5. N Engl J Med. 2022. PMID: 36342113 Clinical Trial.

References

    1. Das Pradhan A, Glynn RJ, Fruchart J‐C, et al. Triglyceride lowering with pemafibrate to reduce cardiovascular risk. N Engl J Med 2022; 387: 1923–1934. - PubMed
    1. Sampson M, Wolska A, Warnick R, et al. A New equation based on the standard lipid panel for calculating small dense low‐density lipoprotein‐cholesterol and its use as a risk‐enhancer test. Clin Chem 2021; 67: 987–997. - PMC - PubMed
    1. Ito Y, Fujimura M, Ohta M, et al. Development of a homogeneous assay for measurement of small dense LDL cholesterol. Clin Chem 2011; 57: 57–65. - PubMed
    1. Minamizuka T, Kobayashi J, Tada H, et al. Detailed analysis of lipolytic enzymes in a Japanese woman of familial lipoprotein lipase deficiency ‐ effects of pemafibrate treatment. Clin Chim Acta 2020; 510: 216–219. - PubMed