Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr;182(4):1627-1635.
doi: 10.1007/s00431-023-04842-3. Epub 2023 Jan 28.

Development and validation of a model for predicting the adult height of girls with idiopathic central precocious puberty

Wenyong Wu  1 , Xiaoyun Zhu  1 , Yun Chen  1 , Xiaohong Yang  1 , Ying Zhang  1 , Ruimin Chen  2
Affiliations

Development and validation of a model for predicting the adult height of girls with idiopathic central precocious puberty

Wenyong Wu et al. Eur J Pediatr. 2023 Apr.

Abstract

The aim was to develop a model to predict the adult height (AH) of idiopathic central precocious puberty (ICPP) girls who underwent gonadotropin-releasing hormone analog (GnRHa) treatment. Data analysis included 258 girls with ICPP. Among them, 101 girls who reached final AH (FAH) with GnRHa treatment were analyzed to verify three previous prediction models and develop a unique model based on multiple linear regression. The control group consisted of 41 untreated ICPP girls. Moreover, 116 girls treated with GnRHa who almost attained FAH were included for external validation. Based on our cohorts, all of the three previously published models underestimated the FAH with an R of 0.667, 0.793, and 0.664. The AH prediction model was built as follows: Calculated AH (cm) = 1.89630 * Height SDS + 2.29927 * Height SDS for bone age + 0.40776 * Target height + 100.16684 (R2 = 0.66 and adjusted R2 = 0.65). Internal validation showed a mean root mean squared error (RMSE) of 2.16 cm and a mean absolute error (MAE) of 1.64 cm. External validation showed that a significant error (> 1 SD) appeared only in 7 of 116 girls (6.0%). The model is displayed on the website: http://cpppredict.shinyapps.io/dynnomapp .

Conclusion: A model for predicting the AH of girls with ICPP was developed incorporating the variables of height SDS, height SDS for bone age, and target height. The internal and external validation ensures an appropriate degree of discrimination and calibration of the prediction model.

What is known: • Uncertainty prevails as how to predict the adult height of patients with central precocious puberty following gonadotropin-releasing hormone analog treatment. • Previous models for predicting adult height of girls with idiopathic central precocious puberty have not been proven translational to the Chinese population.

What is new: • This study develops a new model for predicting the adult height of idiopathic central precocious puberty girls who underwent gonadotropin-releasing hormone analog treatment. • The internal and external validation assures a good degree of discrimination and calibration of the prediction model in this study.

Keywords: Central precocious puberty; Final adult height; Gonadotropin-releasing hormone analog; Long-term safety; Prediction model.

PubMed Disclaimer

References

    1. Kletter GB, Klein KO, Wong YY (2015) A pediatrician’s guide to central precocious puberty. Clin Pediatr (Phila) 54:414–424. https://doi.org/10.1177/0009922814541807 - DOI - PubMed
    1. Kumar M, Mukhopadhyay S, Dutta D (2015) Challenges and controversies in diagnosis and management of gonadotropin dependent precocious puberty: an Indian perspective. Indian J Endocrinol Metab 19:228–235. https://doi.org/10.4103/2230-8210.149316 - DOI - PubMed - PMC
    1. Luo X, Liang Y, Hou L, Wu W, Ying Y, Ye F (2021) Long-term efficacy and safety of gonadotropin-releasing hormone analog treatment in children with idiopathic central precocious puberty: a systematic review and meta-analysis. Clin Endocrinol (Oxf) 94:786–796. https://doi.org/10.1111/cen.14410 - DOI - PubMed
    1. Latronico AC, Brito VN, Carel JC (2016) Causes, diagnosis, and treatment of central precocious puberty. Lancet Diabetes Endocrinol 4:265–274. https://doi.org/10.1016/S2213-8587(15)00380-0 - DOI - PubMed
    1. Pienkowski C, Tauber M (2016) Gonadotropin-releasing hormone agonist treatment in sexual precocity. Endocr Dev 29:214–229. https://doi.org/10.1159/000438893 - DOI - PubMed

Substances

LinkOut - more resources