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. 2023 Jan 1;24(1):321-329.
doi: 10.31557/APJCP.2023.24.1.321.

Profiling the Expression and Prognostic Values of FYN, A Non-Receptor Tyrosine Kinase, in Different Histological Types of Epithelial Ovarian Cancer

Wiyada Dankai  1 , Surapan Khunamornpong  1 , Prapaporn Suprasert  2 , Suree Lekawanvijit  1
Affiliations

Profiling the Expression and Prognostic Values of FYN, A Non-Receptor Tyrosine Kinase, in Different Histological Types of Epithelial Ovarian Cancer

Wiyada Dankai et al. Asian Pac J Cancer Prev. .

Abstract

Objective: This study was aimed at evaluating FYN expression among different histologic types of epithelial ovarian cancer (EOC) and its associated prognostics.

Methods: The FYN expression levels using quantitative real-time PCR method were evaluated in 98 primary EOC. Receiver operating characteristic curve were used to select an optimal cut-off value for determining the presence or absence of a disease progression.

Result: The median level of FYN expression varied among different EOC types, being the highest in high-grade serous carcinomas and the lowest in clear cell carcinomas (CCC). Using the cutoff FYN value to predict disease progression, the FYN-positive group had a poorer progression-free survival (PFS) compared to the FYN-negative group (p = 0.001). In multivariate Cox regression analysis, FYN expression was an independent predictor for disease progression (Hazard ratio = 2.30; 95% CI: 1.21- 4.38; p = 0.011). In subgroup analysis, FYN expression was significantly associated with lower PFS in early stage CCC patients (p = 0.009).

Conclusion: FYN expression is variable among different types of EOC while impacting on the prognostic values in patients with early stage CCC.

Keywords: Fyn; Ovarian Cancer; clear cell carcinomas; disease progression; non-receptor tyrosine kinase protein.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
The Expression Levels of FYN mRNA in Differentiating Histological Subtypes of Ovarian Cancer (Kruskal-Wallis equality-of-populations rank test, p= 0.0006)
Figure 2
Figure 2
The Relative Expression Levels of FYN mRNA between the EOC Patient Groups with and without Disease Progression (Mann-Whitney U test, p = 0.0005)
Figure 3
Figure 3
The ROC Curve Analysis of FYN Expression for Prediction of Disease Progression in EOC Patients
Figure 4
Figure 4
Kaplan-Meier Progression-Free Survival Plot of EOC Patients Stratified by FYN Expression Status (log-rank test; p = 0.0012)
Figure 5
Figure 5
Kaplan-Meier Progression-Free Survival Plots of Patients with Different Types of EOC stratified by FYN expression status. A, clear cell carcinomas (CCC); B, high-grade serous carcinomas (HGSC); C, other high-grade carcinomas; D, low-grade carcinomas
Figure 6
Figure 6
Kaplan-Meier Progression-Free Survival Plots of Patients with Different Types of EOC Stratified by FYN Expression and FIGO Stage. A, clear cell carcinomas (CCC); B, high-grade serous carcinomas (HGSC); C, other high-grade carcinomas; D, low-grade carcinomas
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