Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2023 Jan 29;12(1):4.
doi: 10.1186/s13756-023-01210-6.

The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis

Amir Hossein Hasanpour  1 , Mahdi Sepidarkish  2 , Abolfazl Mollalo  3 , Ali Ardekani  4 , Mustafa Almukhtar  5 , Amal Mechaal  6 , Seyed Reza Hosseini  7 , Masoumeh Bayani  7 , Mostafa Javanian  8 , Ali Rostami  9
Affiliations
Meta-Analysis

The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis

Amir Hossein Hasanpour et al. Antimicrob Resist Infect Control. .

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult to treat infection, particularly in residents of elderly care centers (ECCs). Despite the substantial burden of MRSA, an inadequate number of studies have analyzed MRSA prevalence in ECCs.

Objectives: We conducted a worldwide systematic review and meta-analysis on the prevalence and risk factors of MRSA in ECCs.

Methods: We searched MEDLINE/PubMed, EMBASE, Web of Science, and Scopus databases and the gray literature sources for all studies published between January 1980 and December 2022 on the prevalence of MRSA in ECCs. A random-effects model was utilized to estimate pooled prevalence rates at 95% confidence intervals (CI). Moreover, the data were analyzed based on World Health Organization-defined regions, income, and human development index levels.

Results: In total, 119 studies, including 164,717 participants from 29 countries, were found eligible for meta-analysis. The pooled global prevalence of MRSA was 14.69% (95% CI 12.39-17.15%; 16,793/164,717). Male gender [prevalence ratio (PR) = 1.55; 95% CI 1.47-1.64], previous MRSA infection (PR = 3.71; 95% CI 3.44-4.01), prior use of antibiotics (PR = 1.97; 95% CI 1.83-2.12), hospitalized within the previous year (PR = 1.32; 95% CI 1.20-1.45), have had any wound (PR = 2.38; 95% CI 2.23-2.55), have used urinary catheter (PR = 2.24; 95% CI 2.06-2.43), have used any medical device (PR = 1.78; 95% CI 1.66-1.91), and those with diabetes (PR = 1.55; CI 1.43-1.67) were more likely to be colonized by MRSA than other patients.

Conclusion: Screening programs and preventive measures should target MRSA in ECCs due to the high global prevalence rates.

Keywords: Long-term care; Methicillin-resistant Staphylococcus aureus; Nursing homes; Residential facilities; Systematic review.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The PRISMA diagram of the study selection
Fig. 2
Fig. 2
Worldwide distribution of MRSA colonization in ECCs
Fig. 3
Fig. 3
Meta-regression analyses of MRSA prevalence among elderly living in ECCs concerning A Country's gross national income per capita, B HDI level and C Publication year
See this image and copyright information in PMC

References

    1. Suzman R, Beard JR, Boerma T, Chatterji S. Health in an ageing world—what do we know? Lancet. 2015;385(9967):484–486. - PubMed
    1. Wong JW, Ip M, Tang A, Wei VW, Wong SY, Riley S, Read JM, Kwok KO. Prevalence and risk factors of community-associated methicillin-resistant Staphylococcus aureus carriage in Asia-Pacific region from 2000 to 2016: a systematic review and meta-analysis. Clin Epidemiol. 2018;10:1489–1501. - PMC - PubMed
    1. Naja S, Din Makhlouf MME, Chehab MAH. An ageing world of the 21st century: a literature review. Int J Community Med Public Health. 2017;4(12):4363–4369.
    1. Tarakcı E, Zenginler Y, Kaya Mutlu E. Chronic pain, depression symptoms and daily living independency level among geriatrics in nursing home. Agri. 2015;27(1):35–41. - PubMed
    1. McClean P, Hughes C, Tunney M, Goossens H, Jans B, Group obotESoACNHP. Jans B, Stroobants R, Goossens H, Budimir A, et al. Antimicrobial prescribing in European nursing homes. J Antimicrob Chemother. 2011;66(7):1609–1616. - PubMed

LinkOut - more resources