Bixin-loaded colloidal nanodelivery systems, techniques and applications

Ayesheh Enayati¹, Atefe Rezaei², Seid Reza Falsafi³, Hadis Rostamabadi⁴, Narjes Malekjani⁵, Sahar Akhavan-Mahdavi⁶, Mohammad Saeed Kharazmi⁷, Seid Mahdi Jafari⁸

Affiliations

¹ Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
² Department of Food Science and Technology, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
⁴ Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
⁵ Department of Food Science and Technology, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran.
⁶ Faculty of Food Science and Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
⁷ Faculty of Medicine, University of California, Riverside, USA.
⁸ Faculty of Food Science and Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran; Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E-32004 Ourense, Spain; College of Food Science and Technology, Hebei Agricultural University, Baoding 071001, China. Electronic address: smjafari@gau.ac.ir.

PMID: 36709686
DOI: 10.1016/j.foodchem.2023.135479

Review

Bixin-loaded colloidal nanodelivery systems, techniques and applications

Ayesheh Enayati et al. Food Chem. 2023.

. 2023 Jun 30:412:135479.

doi: 10.1016/j.foodchem.2023.135479. Epub 2023 Jan 16.

Authors

Ayesheh Enayati¹, Atefe Rezaei², Seid Reza Falsafi³, Hadis Rostamabadi⁴, Narjes Malekjani⁵, Sahar Akhavan-Mahdavi⁶, Mohammad Saeed Kharazmi⁷, Seid Mahdi Jafari⁸

Affiliations

¹ Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
² Department of Food Science and Technology, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
⁴ Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
⁵ Department of Food Science and Technology, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran.
⁶ Faculty of Food Science and Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
⁷ Faculty of Medicine, University of California, Riverside, USA.
⁸ Faculty of Food Science and Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran; Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E-32004 Ourense, Spain; College of Food Science and Technology, Hebei Agricultural University, Baoding 071001, China. Electronic address: smjafari@gau.ac.ir.

PMID: 36709686
DOI: 10.1016/j.foodchem.2023.135479

Abstract

Bixin is the cis-carotenoid from the seed of achiote tree or annatto. It is an approved liposoluble apocarotenoid by FDA as colorant and additive in the food industry. Nonetheless, bixin is unstable in the presence of oxygen, light, high pHs (alkali) and heat; thereby reducing its bioavailability/bioactivity, and also, with a low solubility in water. Some biopolymeric (e.g., nanofibers, nanogels, and nanotubes) and lipid-based nanocarriers (nanoliposomes, niosomes, hexosomes, nanoemulsions, solid-lipid nanoparticles, and nanostructured lipid carriers) have been introduced for bixin. Thus, this review focuses on the updated information regarding bixin-loaded nanodelivery platforms. Moreover, it provides a comprehensive review of bioavailability, physicochemical properties, and applications of nanoencapsulated-bixin as an additive, its release rate and safety issues. These findings will bring potential strategies for the usage of nanocarriers in managing bixin defaults to improve its broad application in various industries.

Keywords: Bioavailability; Bixin; Food industry; Health benefits; Nanocarriers; Nanoencapsulation.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Bixin-loaded colloidal nanodelivery systems, techniques and applications

Affiliations

Bixin-loaded colloidal nanodelivery systems, techniques and applications

Authors

Affiliations

Abstract

Conflict of interest statement

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MeSH terms

Substances

LinkOut - more resources

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