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Review
. 2023 Jan 10:9:1040259.
doi: 10.3389/fnut.2022.1040259. eCollection 2022.

Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

Mohamed T El-Saadony  1 , Tao Yang  2 , Sameh A Korma  3 , Mahmoud Sitohy  4 , Taia A Abd El-Mageed  5 , Samy Selim  6 , Soad K Al Jaouni  7 , Heba M Salem  8 , Yasser Mahmmod  9 , Soliman M Soliman  10 , Shaimaa A A Mo'men  11 , Walid F A Mosa  12 , Nahed A El-Wafai  1 , Hamed E Abou-Aly  13 , Basel Sitohy  14   15 , Mohamed E Abd El-Hack  16 , Khaled A El-Tarabily  17   18   19 , Ahmed M Saad  4
Affiliations
Review

Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

Mohamed T El-Saadony et al. Front Nutr. .

Abstract

The yellow polyphenolic pigment known as curcumin, originating from the rhizome of the turmeric plant Curcuma longa L., has been utilized for ages in ancient medicine, as well as in cooking and food coloring. Recently, the biological activities of turmeric and curcumin have been thoroughly investigated. The studies mainly focused on their antioxidant, antitumor, anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective impacts. This review seeks to provide an in-depth, detailed discussion of curcumin usage within the food processing industries and its effect on health support and disease prevention. Curcumin's bioavailability, bio-efficacy, and bio-safety characteristics, as well as its side effects and quality standards, are also discussed. Finally, curcumin's multifaceted uses, food appeal enhancement, agro-industrial techniques counteracting its instability and low bioavailability, nanotechnology and focused drug delivery systems to increase its bioavailability, and prospective clinical use tactics are all discussed.

Keywords: bioavailability; cancer; curcumin; dietary additives; herbal treatment; metabolism; polyphenolic pigment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Novel methods to increase curcumin bioavailability.
FIGURE 2
FIGURE 2
The effect of pH on curcumin color and its application in food shelf-life. TVBN, Total volatile base nitrogen.
FIGURE 3
FIGURE 3
Phase I and Phase II metabolism of curcumin in epithelium cells.
FIGURE 4
FIGURE 4
Health benefit of bioavailable curcumin.
FIGURE 5
FIGURE 5
Antimicrobial mechanism of bioavailable curcumin against pathogenic microorganisms.
FIGURE 6
FIGURE 6
Antibiofilm mechanism of bioavailable curcumin against pathogenic microorganisms.
FIGURE 7
FIGURE 7
Anti-inflammatory mechanism of bioavailable curcumin.
FIGURE 8
FIGURE 8
Anticancer mechanism of bioavailable curcumin against numerous types of cancer.
See this image and copyright information in PMC

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