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. 2023 Jan 13:9:1040167.
doi: 10.3389/fnut.2022.1040167. eCollection 2022.

Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review

Carlos Ramos Urrea  1 , Amanda Paula Pedroso  1 , Fernanda Thomazini  1 , Andreia Cristina Feitosa do Carmo  2 , Mônica Marques Telles  1 , Ana Lydia Sawaya  1 , Maria do Carmo Pinho Franco  1 , Eliane Beraldi Ribeiro  1
Affiliations

Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review

Carlos Ramos Urrea et al. Front Nutr. .

Abstract

Introduction: Thyroid hormones exert multiple physiological effects essential to the maintenance of basal metabolic rate (BMR), adaptive thermogenesis, fat metabolism, growth, and appetite. The links between obesity and the hormones of the thyroid axis, i.e., triiodothyronine (T3), thyroxine (T4), and thyrotropin (TSH), are still controversial, especially when considering children and adolescents. This population has high rates of overweight and obesity and several treatment approaches, including nutritional, psychological, and physical exercise interventions have been used. Understanding the importance of the hormones of the thyroid axis in the recovery from overweight and obesity may help directing measures to the maintenance of a healthy body composition. The present scoping review was carried out to analyze studies evaluating these hormonal levels throughout interventions directed at treating overweight and obesity in children and adolescents. The main purpose was to ascertain whether the hormones levels vary during weight loss.

Methods: We selected for analysis 19 studies published between 1999 and 2022.

Results: Most of the studies showed that changes in different anthropometric indicators, in response to the multidisciplinary interventions, correlated positively with free T3 (fT3), total T3 (TT3), and TSH. With respect to free T4 (fT4) and total T4 (TT4).

Discussion: The most common finding was of unchanged levels and, hence, no significant association with weight loss. Moreover, thyroxine supplementation has failed to affect the response to the interventions. Further studies are necessary to elucidate the relevance of the variations in hormone levels to the establishment of overweight/obesity and to the recovery from these conditions in children/adolescents.

Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42020203359.

Keywords: adolescent; children; multidisciplinary intervention; obesity; recovery; thyroid hormones.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flow diagram of the studies’ selection.
See this image and copyright information in PMC

References

    1. World Health Organization [WHO]. Guideline: Assessing and Managing Children at Primary Health-care Facilities to Prevent Overweight and Obesity in the Context of the Double Burden of Malnutrition: Updates for the Integrated Management of Childhood Illness (IMCI). (2017) Geneva: World Health Organization. - PubMed
    1. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128⋅9 million children, adolescents, and adults. Lancet. (2017) 390:2627–42. - PMC - PubMed
    1. Abdullah A, Aceh B, De Courten M, Stevenson CE, Walls H. The number of years lived with obesity and the risk of all-cause and cause-specific mortality. Int J Epidemiol. (2011) 50:985–96. 10.1093/ije/dyr018 - DOI - PubMed
    1. Mullur R, Liu Y, Brent G. Thyroid hormone regulation of metabolism. Physiol Rev. (2014) 94:355–82. 10.1152/physrev.00030.2013 - DOI - PMC - PubMed
    1. Witkowska-Sêdek E, Kucharska A, Rumińska M, Pyrzak B. Thyroid dysfunction in obese and overweight children. Endokrynol Pol. (2017) 68:54–60. 10.5603/EP.2017.0007 - DOI - PubMed

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