Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov 16:10.1002/elan.202200295.
doi: 10.1002/elan.202200295. Online ahead of print.

Voltammetric Determination of Favipiravir Used as an Antiviral Drug for the Treatment of Covid-19 at Pencil Graphite Electrode

Teslime Erşan  1 , Didem Giray Dilgin  2 , Elif Kumrulu  3 , Umur Kumrulu  3 , Yusuf Dilgin  1
Affiliations

Voltammetric Determination of Favipiravir Used as an Antiviral Drug for the Treatment of Covid-19 at Pencil Graphite Electrode

Teslime Erşan et al. Electroanalysis. .

Abstract

This work describes the sensitive voltammetric determination of favipiravir (FAV) based on its reduction for the first time with a low-cost and disposable pencil graphite electrode (PGE). In addition, the determination of FAV was also performed based on its oxidation. Differential pulse (DP) voltammograms recorded in 0.5 M H2SO4 for the reduction of FAV show that peak currents increase linearly in the range of 1.0 to 600.0 μM with a limit of detection of 0.35 μM. The acceptable recovery values (98.9-106.0 %) obtained from a pharmaceutical tablet, real human urine, and artificial blood serum samples spiked with FAV confirm the high accuracy of the proposed method.

Keywords: COVID-19; Differential Pulse Voltammetry; Favipiravir; Pencil graphite electrode.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Plots of peak potentials of reduction (A) and oxidation (B) of FAV versus pH.
Figure 2
Figure 2
Cyclic Voltammograms of FAV (1.0×10−4 M) at PGE based on its reduction in 0.10 M H2SO4 at varying scan rates (B). Plots of peak current vs. square root of scan rate (B), log current vs. log scan rate (C), and peak potential vs. log scan rate (D).
Figure 3
Figure 3
Cyclic Voltammograms of (5.0×10−4 M) at PGE based on its oxidation in pH 5.0 BRBS containing 0.10 M KCl at varying scan rates (B). Plots of peak current vs. square root of scan rate (B), log current vs. log scan rate (C), and peak potential vs. log scan rate (D).
Figure 4
Figure 4
Reduction and oxidation mechanism of FAV at PGE.
Figure 5
Figure 5
DP voltammograms of FAV scanned towards the cathodic direction at varying concentrations in the range of 1.0 to 1000.0 μM under optimized conditions (Pam=120 mV, Pt: 1 ms, Estep: 6 mV, and scan rate: 25 mV/s). Dynamic range and calibration curves.
Figure 6
Figure 6
DP voltammograms of FAV scanned towards the anodic direction at varying concentrations in the range of 5.0 to 1000.0 μM under optimized conditions (Pam=120 mV, Pt: 3 ms, Estep: 6 mV, and scan rate: 25 mV/s). Dynamic range and calibration curves.
See this image and copyright information in PMC

References

    1. Covid 19–2020. https://www.who.int/director-general/speeches/detail/who-director-genera....
    1. Covid 19 2022. https://covid19.who.int/. Accessed 23 August 2022.
    1. Cucinotta D., Vanelli M., Acta Biol. Med. 2020, 91, 157–160. - PMC - PubMed
    1. Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., Cheng Z., Yu T., Xia J., Wei Y., Wu W., Xie X., Yin W., Li H., Liu M., Xiao Y., Gao H., Guo L., Xie J., Wang G., Jiang R., Gao Z., Jin Q., Wang J., Cao B., Lancet 2020, 395 (10223), 497–506. - PMC - PubMed
    1. Woelfel R., Corman V. M., Guggemos W., Seilmaier M., Zange S., Mueller M. A., Niemeyer D., Vollmar P., Rothe C., Hoelscher M., Bleicker T., Bruenink S., Schneider J., Ehmann R., Zwirglmaier K., Drosten C., Wendtner C., Nature 2020, 581, 465–469. - PubMed

LinkOut - more resources