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. 2023 Jan 22:16:297-309.
doi: 10.2147/JIR.S385220. eCollection 2023.

Systemic Inflammation Markers Associated with Bone Mineral Density in perimenopausal and Postmenopausal Women

Yijie Chen #  1 , Jingjing Yu #  2 , Lan Shi  1 , Shuyang Han  1 , Jun Chen  1 , Zhumei Sheng  3 , Miao Deng  3 , Xuejing Jin  1   3 , Zhifen Zhang  1   3
Affiliations

Systemic Inflammation Markers Associated with Bone Mineral Density in perimenopausal and Postmenopausal Women

Yijie Chen et al. J Inflamm Res. .

Abstract

Objective: The aim of this research was to determine whether systemic inflammatory indicators, including aggregate index of systemic inflammation (AISI), neutrophils lymphocyte to platelet ratio (NLPR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), are related to bone mineral density (BMD) in perimenopausal and postmenopausal women.

Methods: One hundred and eighty-one perimenopausal and 390 postmenopausal women were enrolled in this cross-sectional study. Continuous variables by analysis of variance and Kruskal Wallis test for comparing the clinical characteristics. Linear regression analysis was conducted to investigate the associations between inflammatory indicators with BMD. The comparison between the subgroups was performed using the nonparametric test and the T-test.

Results: AISI, NLPR, SII, and SIRI quartile values were inversely associated with BMD in menopausal women (P = 0.021; P = 0.047; P < 0.001; P < 0.001, respectively). After adjusting for confounding factors, four inflammatory indicators remained significantly associated with BMD (all P for trend <0.001). Analysis according to menopausal status demonstrated that AISI, SII, and SIRI were significantly correlated with mean femoral neck BMD in postmenopausal women (P for trend = 0.015, 0.004, and 0.001), but not significantly associated with BMD in perimenopausal women (P for trend = 0.248, 0.054, and 0.352) after adjustment for covariates.

Conclusion: The quartile values of AISI, SII, and SIRI were inversely associated with BMD in postmenopausal women, following adjustment for individual variables, hormone profiles and glucolipid metabolism profiles. AISI, SII, and SIRI have potential to be important tools for screening and prevention of bone loss in menopausal women in future clinical practice.

Keywords: cross-sectional studies; female; femur neck; inflammation; menopause; regression analysis.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Femoral neck BMD across quartiles of AISI in perimenopausal and postmenopausal women.
Figure 2
Figure 2
Femoral neck BMD across quartiles of NLPR in perimenopausal and postmenopausal women.
Figure 3
Figure 3
Femoral neck BMD across quartiles of SII in perimenopausal and postmenopausal women.
Figure 4
Figure 4
Femoral neck BMD across quartiles of SIRI in perimenopausal and postmenopausal women.
See this image and copyright information in PMC

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References

    1. Arceo-Mendoza RM, Camacho PM. Postmenopausal osteoporosis: latest guidelines. Endocrinol Metab Clin North Am. 2021;50:167–178. doi:10.1016/j.ecl.2021.03.009 - DOI - PubMed
    1. Wang L, Yu W, Yin X, et al. Prevalence of osteoporosis and fracture in China: the China Osteoporosis Prevalence Study. JAMA Netw Open. 2021;4:e2121106. doi:10.1001/jamanetworkopen.2021.21106 - DOI - PMC - PubMed
    1. Williams SA, Daigle SG, Weiss R, Wang Y, Arora T, Curtis JR. Economic burden of osteoporosis-related fractures in the US Medicare population. Ann Pharmacother. 2021;55:821–829. doi:10.1177/1060028020970518 - DOI - PMC - PubMed
    1. Hagino H, Osaki M, Okuda R, Enokida S, Nagashima H. Recent trends in the incidence of Hip fracture in Tottori Prefecture, Japan: changes over 32 years. Arch Osteoporos. 2020;15:152. doi:10.1007/s11657-020-00823-3 - DOI - PMC - PubMed
    1. Wu D, Cline-Smith A, Shashkova E, Perla A, Katyal A, Aurora R. T-cell mediated inflammation in postmenopausal osteoporosis. Front Immunol. 2021;12:687551. doi:10.3389/fimmu.2021.687551 - DOI - PMC - PubMed