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Review
. 2023 Jan 19:2023:7443226.
doi: 10.1155/2023/7443226. eCollection 2023.

Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia?

Ming Lu  1 , Jian Liu  1 , Xikun Wu  1 , Zhiqing Zhang  1
Affiliations
Review

Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia?

Ming Lu et al. Biomed Res Int. .

Abstract

Ciprofol is a novel compound that was independently developed in China. According to the Chinese product instructions approved by the China National Medical Products Administration and the information of official website, indications for ciprofol include sedation and anesthesia during the surgical/procedure of nontracheal intubation, induction and maintenance of general anesthesia, and sedation during intensive care. Ciprofol is a short-acting intravenous sedative based on the structural modification of propofol. Ciprofol has high efficacy, good selectivity, and fewer adverse reactions, indicating good clinical application potential. A series of clinical studies have been conducted to evaluate the sedative effect of ciprofol in various procedures and settings, including gastroscopy and colonoscopy, fiber-optic bronchoscopy, general anesthesia in elective surgeries, and mechanical ventilation in intensive care units. This review summarizes the chemical structure, pharmacodynamics, and pharmacokinetic properties of ciprofol. We also assessed the efficacy and safety of ciprofol by synthesizing the relevant clinical trial data.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
Chemical structures of propofol and ciprofol.
Figure 2
Figure 2
Plasma concentration-time curves of ciprofol in the elderly and nonelderly patients.
See this image and copyright information in PMC

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