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. 2020;3(4):90-96.
doi: 10.26502/anu.2644-2833025. Epub 2020 Oct 1.

Penile Paget's Disease: A Case Report and Review of the Literature

R C Flanigan  1 , R Dornbier  1 , M L Quek  1 , M Woods  1 , A Gorbonos  1 , G Gupta  1 , M M Harkenrider  2 , A Solanki  2 , A Badami  3 , E Henry  3 , S Berg  3 , D Bova  4 , G A Barkan  5 , M M Picken  5
Affiliations

Penile Paget's Disease: A Case Report and Review of the Literature

R C Flanigan et al. Arch Nephrol Urol. 2020.

Abstract

Extramammary Paget's Disease (EMPD) is a rare cutaneous, slow growing, intraepithelial adenocarcinoma that can be either primary (intraepithelial arising within the epidermis) or secondary (intraepithelial spread of a visceral carcinoma). Here we present the case of a 63-year-old male with EMPD of the glans penis stemming from underlying urothelial carcinoma. Our treatment decision elected for management with chemotherapy and local treatment with radiation therapy. Subsequent, review of the literature demonstrated a rare disease with a variety of underlying malignancies causing this secondary pathology. Caregivers should be aware of the association of Paget's disease and urothelial cancer and should have a high index of suspicion that erythematous penile lesions may represent Paget's disease and that penile biopsies should be performed early in this setting.

Keywords: Adenocarcinoma; Extramammary Paget’s Disease; Urothelial carcinoma.

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Figures

Figure 1:
Figure 1:
Gross image showing erythema of the penile glans.
Figure 2:
Figure 2:
A. H&E stained section showing intraepidermal atypical epithelial cells, some of which with a clear cytoplasm. B. Immunohistochemical stain for GATA3 shows diffuse and strong positivity in the atypical cells. A and B original magnification x100.
See this image and copyright information in PMC

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