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Review
. 2023 Jan 12:10:1075738.
doi: 10.3389/fped.2022.1075738. eCollection 2022.

Osteocalcin serum concentrations and markers of energetic metabolism in pediatric patients. Systematic review and metanalysis

Silvia Rodríguez-Narciso  1 , Raigam Jafet Martínez-Portilla  2   3 , Iris Paola Guzmán-Guzmán  4 , Gabriela Careaga-Cárdenas  5 , Brenda Jazmin Rubio-Navarro  5 , Luis Fernando Barba-Gallardo  5 , Rodolfo Delgadillo-Castañeda  6 , José Rafael Villafan-Bernal  3   7   8
Affiliations
Review

Osteocalcin serum concentrations and markers of energetic metabolism in pediatric patients. Systematic review and metanalysis

Silvia Rodríguez-Narciso et al. Front Pediatr. .

Abstract

Background: Osteocalcin plays a role in glucose metabolism in mice, but its relevance in human energetic metabolism is controversial. Its relationship with markers of energetic metabolism in the pediatric population has not been systematically addressed in infants and adolescents.

Objective: This study aims to assess the mean differences between tOC, ucOC, and cOC among healthy children and children with type 1 or type 2 diabetes (T1D or T2D) and the correlation of these bone molecules with metabolic markers.

Methods: A systematic review and metanalysis were performed following PRISMA criteria to identify relevant observational studies published in English and Spanish using PubMed, Scopus, EBSCO, and Web of Science databases. The risk of bias was assessed using New Castle-Ottawa scale. Effect size measures comprised standardized mean difference (SMD) and Pearson correlations. Heterogeneity and meta-regressions were performed.

Results: The 20 studies included were of high quality and comprised 3,000 pediatric patients who underwent tOC, cOC, or ucOC measurements. Among healthy subjects, there was a positive correlation of ucOC with WC and weight, a positive correlation of tOC with FPG, HDL-c, WC, height, and weight, and a negative correlation between tOC and HbA1c. Among diabetic subjects, a negative correlation of ucOC with HbA1c and glycemia in both T1D and T2D was found and a negative correlation between tOC and HbA1c in T1D but not in T2D. The ucOC concentrations were lower in T2D, T1D, and patients with abnormal glucose status than among controls. The serum concentrations of tOC concentrations were lower among T1D than in controls. The patient's age, altitude, and HbA1c influenced the levels of serum tOC.

Conclusion: Osteocalcin is involved in energy metabolism in pediatric subjects because it is consistently related to metabolic and anthropometric parameters.

Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42019138283.

Keywords: energetic metabolism; glucose - insulin; osteocalcin; pediatric patient; systematic review & meta-analysis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram of the study.
Figure 2
Figure 2
Forest plot with the individual results and the pooled estimates of tOC serum levels among T1D and controls.
Figure 3
Figure 3
Baujat plot for analysis of the contribution of each study to heterogeneity in tOC serum levels.
Figure 4
Figure 4
Forest plot with the individual results and the pooled estimates of ucOC serum levels among patients with abnormal glycemic status and controls.
Figure 5
Figure 5
Forest plot with the individual results and the pooled estimates of the Pearson correlation coefficients (COR) of ucOC serum levels with HbA1c and glycemia among T1D and T2D pediatric patients.
Figure 6
Figure 6
Meta-regressions showing variables influencing the serum levels of tOC in pediatric patients: (A) mean age. (B) Altitude. (C) UV index. (D) Glycated hemoglobin.
See this image and copyright information in PMC

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